ArticleJournal of leukocyte biology2008
CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis.
Article in Journal of leukocyte biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Novel oral adjuvant to enhance cytotoxic memory like NK cell responses in HIV vaccine platform.NPJ vaccines · 2025Article
- Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8Nature immunology · 2022Observational
- The peripheral and decidual immune cell profiles in women with recurrent pregnancy loss.Frontiers in immunology · 2022Article
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- Natural killer cell monitoring in cutaneous melanoma - new dynamic biomarker.Oncology letters · 2019Article
- Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice.Endocrinology · 2017Article
- Expression pattern of CD11c on lung immune cells after disseminated murine cytomegalovirus infection.Virology journal · 2017Article
- Early Differentiation of Human CD11cJournal of immunology research · 2016Article
- Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Flow cytometric detection of p38 MAPK phosphorylation and intracellular cytokine expression in peripheral blood subpopulations from patients with autoimmune rheumatic diseases.Journal of immunology research · 2014Article
- Memory NK cells: why do they reside in the liver?Cellular & molecular immunology · 2013Review
- Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression.Hepatology (Baltimore, Md.) · 2012Article
- Natural killer cells in non-hematopoietic malignancies.Frontiers in immunology · 2012Article
- Development of murine hepatic NK cells during ontogeny: comparison with spleen NK cells.Clinical & developmental immunology · 2012Article
- Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases.Journal of leukocyte biology · 2009Review
- Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves.The Journal of experimental medicine · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells (NK1.1(+)CD3(-)) in the murine liver whose function was currently unknown. In naïve animals, CD11c(+) liver NK cells displayed an activated phenotype and possessed enhanced effector functions when compared with CD11c(-) liver NK cells. During the innate response to adenovirus infection, CD11c(+) NK cells were the more common IFN-gamma-producing NK cells in the liver, demonstrated enhanced lytic capability, and gained a modest degree of APC function. The mechanism of IFN-gamma production in vivo depended on TLR9 ligation as well as IL-12 and -18. Taken together, our findings demonstrate that CD11c(+) NK cells are a unique subset of NK cells in the murine liver that contribute to the defense against adenoviral hepatitis.
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Registered trials
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