Evidence map›Paper›PMID 18663545›Full record

Trial reportObesity surgery2008

Sleeve gastrectomy-a "food limiting" operation.

John Melissas, Markos Daskalakis, Sophia Koukouraki, Ioannis Askoxylakis, Maria Metaxari, Efstathios Dimitriadis, Maria Stathaki, John A Papadakis

2 registry-linked trialsAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 136 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 6 pooled it
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02476474 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

Antral Length and GERD Following Sleeve Gastrectomy for Morbid

TypeinterventionalSponsorUniversity of California, San FranciscoRan2023 to 2023Enrolled0ConditionsMorbid ObesityArms3 cm start of resection, 6 cm start of resection
NCT02539641 nacompletednot on this mapstarted 2015, after this paper: background citation

Bariatric Procedures and Changes in Incretins and Gastric Emptying

TypeinterventionalSponsorRijnstate HospitalRan2015 to 2016Enrolled32ConditionsMorbid ObesityArmsGastric emptying scintigraphy, Determination of gut hormones
3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 6 syntheses or guidelines pooled it, 275 citations in OpenAlex.

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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

John MelissasBariatric Unit Department of Surgical Oncology, Heraklion University Hospital, Medical School, University of Crete, 15 Delaporta St., Herarklion 71409, Crete, Greece. melissas@med.uoc.gr
Markos Daskalakis
Sophia Koukouraki
Ioannis Askoxylakis
Maria Metaxari
Efstathios Dimitriadis
Maria Stathaki
John A Papadakis
University of Crete · GRUniversity Hospital of Heraklion · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSleeve gastrectomy (SG), which, thus far, is showing good resolution of comorbidities and good weight loss, shows increasing popularity among bariatric surgeons. The aim of this study was to evaluate clinical outcome and the gastric emptying of solid foods, 24 months after SG.

methodsFourteen morbidly obese patients, four males and ten females, median age 41 years (range 29-65), median body mass index (BMI) 49.46 kg/m(2) (range 41.14-55.63), who underwent SG for weight loss, were studied prospectively. Nine patients underwent gastric emptying studies, using radioisotopic technique before, 6 months and 24 months after the operation. The remaining five patients underwent gastric emptying studies, 6 months and 24 months after the operation.

resultsA significant reduction in patients' weight and BMI was evident at 6, 12 and 24 months postoperatively. In the nine patients who underwent gastric emptying studies pre-, 6 and 24 months postoperatively, the T-lag phase duration significantly decreased, following the SG, from 17.30 (range 15.50-20.90) min, to 12.50 (range 9.20-18.00) min at 6 months and 12.16 (range 10.90-20.00) min at 24 months postoperatively (P < 0.05). The gastric emptying half time (T1/2) accelerated significantly postoperatively from 86.50 (range 77.50-104.60) min, to 62.50 (range 46.30-80.00) min at 6 months and 60.80 (range 54.80-100.00) min at 24 months after SG (P < 0.05). The percentage of gastric emptying (%GE) increased significantly postoperatively, from 52 (range 43-58) % to 72 (range 57-97) % at 6 months and 74 (range 45-82) % at 24 months, following SG (P < 0.05). No differences in gastric emptying were observed, when values at 24 months were compared to those at 6 months postoperatively. When the whole group of 14 patients was studied, there were also no significant changes in T-lag, T1/2 and %GE between 6 and 24 months postoperatively.

conclusionsOur study indicates the constant effect of SG in the acceleration of gastric emptying of solids, which occurs faster, not only in short but also in long-term postoperatively. Such effects on gastric motility, in combination with the reported alterations in gut hormones, may explain how this 'food limiting' operation results in weight loss.

Indexed as

GastrectomyLaparoscopyAdultAgedBody Mass IndexFemaleFollow-Up StudiesGastric EmptyingHumansMaleMiddle AgedObesity, MorbidProspective StudiesTime FactorsTreatment OutcomeWeight Loss

Identifiers

PMID18663545
OpenAlexW2073313925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.