ArticleHistochemistry and cell biology2008
Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Role of mitogens in normal and pathological liver regeneration.Hepatology communications · 2025Review
- Role of Alpha-Fetoprotein (AFP) in Diagnosing Childhood Cancers and Genetic-Related Chronic Diseases.Cancers · 2023Review
- Thyroid Hormone Effect on the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Role of liver progenitors in liver regeneration.Hepatobiliary surgery and nutrition · 2015Review
- Unbalanced distribution of materials: the art of giving rise to hepatocytes from liver stem/progenitor cells.Journal of cellular and molecular medicine · 2014Review
- Role of liver progenitors in acute liver injury.Frontiers in physiology · 2013Review
- Model systems and clinical applications of hepatic stem cells for liver regeneration.Hepatology international · 2012Article
- Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat.PloS one · 2012Article
- Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats.World journal of gastrointestinal pathophysiology · 2011Article
- Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure.World journal of gastroenterology · 2009Article
- State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.Histochemistry and cell biology · 2008Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 2-acetaminofluorene/partial hepatectomy (AAF/Phx) model is widely used to induce oval/progenitor cell proliferation in the rat liver. We have used this model to study the impact of a primary hepatocyte mitogen, triiodothyronine (T3) on the liver regenerating by the recruitment of oval/progenitor cells. Administration of T3 transiently accelerates the proliferation of the oval cells, which is followed by rapid differentiation into small hepatocytes. The oval cell origin of the small hepatocytes has been proven by tracing retrovirally transduced and BrdU marked oval cells. The differentiating oval cells become positive for hepatocyte nuclear factor-4 and start to express hepatocyte specific connexin 32, alpha1 integrin, Prox1, cytochrom P450s, and form CD 26 positive bile canaliculi. At the same time oval cell specific OV-6 and alpha-fetoprotein expression is lost. The upregulation of hepatocyte specific mRNAs: albumin, tyrosine aminotransferase and tryptophan 2,3-dioxygenase detected by real-time PCR also proves hepatocytic maturation. The hepatocytic conversion of oval cells occurs on the seventh day after the Phx in this model while the first small hepatocytes appear 5 days later without T3 treatment. The administration of the primary hepatocyte mitogen T3 accelerates the differentiation of hepatic progenitor cells into hepatocytes in vivo, and that may have therapeutic potential.
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