SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed.

1. Ginsenosides Decrease β-Amyloid Production via Potentiating Capacitative Calcium Entry.Biomolecules & therapeutics · 2024
   Article
2. CaInternational journal of molecular sciences · 2022
   Review
3. Presenilin mutations deregulate mitochondrial CaeLife · 2018
   Article
4. The SERCA2: A Gatekeeper of Neuronal Calcium Homeostasis in the Brain.Cellular and molecular neurobiology · 2018
   Review
5. Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis.Frontiers in molecular neuroscience · 2018
   Article
6. Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies.Frontiers in neuroscience · 2018
   Review
7. Do Copy Number Changes in CACNA2D2, CACNA2D3, and CACNA1D Constitute a Predisposing Risk Factor for Alzheimer's Disease?Frontiers in genetics · 2016
   Article
8. A γ-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans.Genetics · 2015
   Article
9. Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Brain : a journal of neurology · 2014
   Article
10. Primary over-expression of AβPP in muscle does not lead to the development of inclusion body myositis in a new lineage of the MCK-AβPP transgenic mouse.International journal of experimental pathology · 2013
    Article
11. The very many faces of presenilins and the γ-secretase complex.Protoplasma · 2013
    Review
12. Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
13. New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.Cell death & disease · 2011
    Review
14. Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling.Antioxidants & redox signaling · 2011
    Article
15. Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons.Cellular signalling · 2010
    Article

Corrections and comments

• Reprint of
  SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.2008

Authors and funding

7 authors.

Funding

Abstract

PubMed holds no abstract for this paper.