ArticleThe Journal of experimental medicine2008
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.
Article in The Journal of experimental medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution.Nature communications · 2024Article
- Multicolor flow cytometry in clinical samples for platelet signaling assessment.Research and practice in thrombosis and haemostasis · 2023Article
- Review
- Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma.The Journal of international medical research · 2021Article
- Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis.Nature communications · 2021Article
- GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Th1 Cells Rolling on Selectins Trigger DAP12-Dependent Signals That Activate Integrin αLβ2.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.Nature ecology & evolution · 2019Article
- Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice.Blood · 2018Article
- Article
- Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.Circulation research · 2014Review
- CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins.The Biochemical journal · 2013Article
- Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets.Thrombosis research · 2012Article
- Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.The Journal of experimental medicine · 2012Article
- Understanding signal integration through targeted mutations of an adapter protein.FEBS letters · 2010Article
- The SYK tyrosine kinase: a crucial player in diverse biological functions.Nature reviews. Immunology · 2010Review
- Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.Cold Spring Harbor perspectives in biology · 2010Review
- Article
- Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases.The Journal of biological chemistry · 2009Article
- Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.The Journal of allergy and clinical immunology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP76), an adaptor that plays a critical role in platelet activation in vitro, contains three N-terminal tyrosine residues that are essential for its function. We demonstrate that mice containing complementary tyrosine to phenylalanine mutations in Y145 (Y145F) and Y112 and Y128 (Y112/128F) differentially regulate integrin and collagen receptor signaling. We show that mutation of Y145 leads to severe impairment of glycoprotein VI (GPVI)-mediated responses while preserving outside-in integrin signaling. Platelets from Y112/128F mice, although having mild defects in GPVI signaling, exhibit defective actin reorganization after GPVI or alpha IIb beta 3 engagement. The in vivo consequences of these signaling defects correlate with the mild protection from thrombosis seen in Y112/128F mice and the near complete protection observed in Y145F mice. Using genetic complementation, we further demonstrate that all three phosphorylatable tyrosines are required within the same SLP76 molecule to support platelet activation by GPVI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.