ArticleNutrition (Burbank, Los Angeles County, Calif.)2008
Endogenous PYY and NPY mediate tonic Y1- and Y2-mediated absorption in human and mouse colon.
Article in Nutrition (Burbank, Los Angeles County, Calif.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- A signaling hub in the mosquito rectum coordinates reproductive investment after blood feeding.Current biology : CB · 2026Article
- Therapeutic potential of modulating endogenous PYY expression for controlling overweight and obesity: a narrative review.Frontiers in nutrition · 2026Review
- A Signaling Hub in the Mosquito Rectum Coordinates Reproductive Investment After Blood Feeding.bioRxiv : the preprint server for biology · 2025Article
- Neuropeptide Y, a paracrine factor secreted by cancer cells, is an independent regulator of angiogenesis in colon cancer.British journal of cancer · 2022Article
- Human resident gut microbeGut microbes · 2020Article
- Interactions of Gut Endocrine Cells with Epithelium and Neurons.Comprehensive Physiology · 2018Review
- Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.Endocrinology · 2016Article
- Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion.The Journal of physiology · 2016Article
- Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation.Nutrition (Burbank, Los Angeles County, Calif.) · 2011Review
- Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses.Cell metabolism · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
objectiveTo establish the functional significance of endogenous peptide YY (PYY) and neuropeptide Y (NPY) as mediators of Y(1) and Y(2) absorptive tone in colonic mucosa.
methodsFunctional studies utilized descending colon from adult mice (wild type [WT] and peptide nulls) and ex vivo human colonic tissue (from patients undergoing bowel resections) measuring changes in basal ion transport. Peak increases in ion transport to Y(1) or Y(2) antagonists (BIBO3304 300 nM; BIIE0246 1 microM) were pooled (mean +/- SEM) and compared using Student's unpaired t test (P <or= 0.05); some tissues received tetrodotoxin (TTX; 100 nM). PYY-positive L-cell numbers and NPY innervation were also compared.
resultsY(1) and Y(2) tones were present in human and WT mouse colon mucosa and only the latter was TTX sensitive. Y(1) tone was unchanged in NPY(-/-) but was approximately 90% inhibited in PYY(-/-) and abolished in PYYNPY(-/-) colon mucosa. Y(2) tone was reduced approximately 50% in NPY(-/-) and PYY(-/-) tissues and was absent from PYYNPY(-/-) colon. Residual Y(2) and Y(1) tones present in PYY(-/-) mucosa were abolished by TTX. PYY ablation had no apparent effect on NPY innervation and PYY-positive cells were observed at the same frequency in NPY(-/-) (56.7+/-6.8 cells/section) and WT (55.0+/-4.6 cells/section) colons. Double knockouts lacked PYY and NPY expression, but endocrine cells and enteric nerves were present with similar frequencies to those of WT mice.
conclusionEndogenous PYY mediates Y(1) absorptive tone that is epithelial in origin, whereas Y(2) tone is a combination of PYY and NPY mediation.
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