Evidence map›Paper›PMID 18662800›Full record

ReviewThe international journal of biochemistry & cell biology2009

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.

Bharat B Aggarwal, Kuzhuvelil B Harikumar

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The international journal of biochemistry & cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05896878 (The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients), which is not on this map. Cited by 633 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
633citing papers in PubMed, 17 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05896878 naterminatednot on this mapstarted 2023, after this paper: background citation

The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients

TypeinterventionalSponsorHudson MedicalRan2023 to 2024Enrolled1ConditionsPain, Chronic, Opioid Dependence, Opioid Use, Inflammation ChronicArmsRoot.Health Dietary Supplement
3 · Its place in the literature

Who cites it

633 citing papers in PubMed, 17 syntheses or guidelines pooled it, 1,934 citations in OpenAlex.

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573 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bharat B AggarwalDepartment of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. aggarwal@mdanderson.org
Kuzhuvelil B Harikumar
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
TARGETING NF-KB ACTIVATION IN REGULATION OF SYMPTOMS IN PATIENTS WITH MULTIPLEP01CA124787 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI REUBEN, JAMES MARTIN · 2008 to 2012
$10.6M
TRIAL OF CELECOXIB IN LUNG CANCER CHEMOPREVENTIONP01CA091844 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI HONG, WAUN KI · 2001 to 2005
$8.2M
NCI NIH HHS CA16672NCI NIH HHS P01 CA091844NCI NIH HHS P01 CA124787NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Although safe in most cases, ancient treatments are ignored because neither their active component nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (Curcuma longa), which was identified more than a century ago. For centuries it has been known that turmeric exhibits anti-inflammatory activity, but extensive research performed within the past two decades has shown that this activity of turmeric is due to curcumin (diferuloylmethane). This agent has been shown to regulate numerous transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes that have been linked to inflammation. The process of inflammation has been shown to play a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. In the current review, we provide evidence for the potential role of curcumin in the prevention and treatment of various proinflammatory chronic diseases. These features, combined with the pharmacological safety and negligible cost, render curcumin an attractive agent to explore further.

Indexed as

AnimalsAnti-Inflammatory AgentsAntineoplastic AgentsAutoimmune DiseasesCardiovascular DiseasesCurcumaCurcuminCytokinesHumansInflammationLung DiseasesMetabolic DiseasesNeoplasmsNeurodegenerative DiseasesPlant ExtractsAnti-Inflammatory AgentsAntineoplastic AgentsCurcuminCytokinesPlant Extractsturmeric extract

Identifiers

PMID18662800
PMCPMC2637808
OpenAlexW2131357228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.