ArticleJournal of molecular biology2008
The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2.
Article in Journal of molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- ANANASTRA: annotation and enrichment analysis of allele-specific transcription factor binding at SNPs.Nucleic acids research · 2022Article
- CDK9 keeps RNA polymerase II on track.Cellular and molecular life sciences : CMLS · 2021Review
- CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents.Frontiers in oncology · 2021Review
- P-TEFb as A Promising Therapeutic Target.Molecules (Basel, Switzerland) · 2020Review
- Review
- CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.Cell host & microbe · 2015Article
- Role of noncoding RNAs in the regulation of P-TEFb availability and enzymatic activity.BioMed research international · 2014Review
- The transcription factor Mef2 links the Drosophila core clock to Fas2, neuronal morphology, and circadian behavior.Neuron · 2013Article
- HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration.The Journal of clinical investigation · 2012Article
- Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function.Retrovirology · 2012Article
- PKC phosphorylates HEXIM1 and regulates P-TEFb activity.Nucleic acids research · 2012Article
- Effects of myogenin on expression of late muscle genes through MyoD-dependent chromatin remodeling ability of myogenin.Molecules and cells · 2012Article
- Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation.Journal of cellular physiology · 2012Article
- 7SK small nuclear RNA directly affects HMGA1 function in transcription regulation.Nucleic acids research · 2011Article
- CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration.Journal of cell science · 2010Article
- Differential effects of sumoylation on transcription and alternative splicing by transcription elongation regulator 1 (TCERG1).The Journal of biological chemistry · 2010Article
- P-TEFb- the final frontier.Cell division · 2009Article
- A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The positive transcription elongation factor b (P-TEFb), composed of cyclin-dependent kinase 9 and cyclin T1, stimulates the elongation of transcription by hyperphosphorylating the C-terminal region of RNA polymerase II. Aberrant activation of P-TEFb results in manifestations of cardiac hypertrophy in mice, suggesting that P-TEFb is an essential factor for cardiac myocyte function and development. Here, we present evidence that P-TEFb selectively activates transcription mediated by the myocyte enhancer factor 2 (MEF2) family of transcription factors, key regulatory factors for myocyte development. Knockdown of endogenous cyclin T1 in murine C2C12 cells abolishes MEF2-dependent reporter gene expression as well as transcription of endogenous MEF2 target genes, whereas overexpression of P-TEFb enhances MEF2-dependent transcription. P-TEFb interacts with MEF2 both in vitro and in vivo. Activation of MEF2-dependent transcription induced by serum starvation is mediated by a rapid dissociation of P-TEFb from its inhibitory subunit, HEXIM1, and a subsequent recruitment of P-TEFb to MEF2 binding sites in the promoter region of MEF2 target genes. These results indicate that recruitment of P-TEFb is a critical step for stimulation of MEF2-dependent transcription, therefore providing a fundamentally important regulatory mechanism underlying the transcriptional program in muscle cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.