ArticleJournal of experimental & clinical cancer research : CR2008
Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study.
Article in Journal of experimental & clinical cancer research : CR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Systematic evaluation of cancer risk associated with DNMT3B polymorphisms.Journal of cancer research and clinical oncology · 2015Pooled it
- Polymorphism of DNA methyltransferase 3B -149C/T and cancer risk: a meta-analysis.Medical oncology (Northwood, London, England) · 2015Pooled it
- Genetic polymorphism of DNA methyltransferase 3B 149 C>T and risk of colorectal cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies.Molecular biology reports · 2012Pooled it
- Article
- Investigation of the DNMT3B -579 G>T Promoter Polymorphism in Patients with Colorectal Cancer in an Azerbaijani Population.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.Croatian medical journal · 2020Article
- DNMT3B -579 G>T Promoter Polymorphism and the Risk of Gastric Cancer in the West of Iran.Journal of gastrointestinal cancer · 2018Article
- Meta-analysis Reveals No Association of DNMT3B -149 C>T Gene Polymorphism With Overall Cancer Risk.Current genomics · 2016Article
- Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population.World journal of surgical oncology · 2016Article
- Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.Molecular biology reports · 2014Article
- The 46359CT polymorphism of DNMT3B is associated with the risk of cervical cancer.Molecular biology reports · 2013Article
- The role of genetics in the establishment and maintenance of the epigenome.Cellular and molecular life sciences : CMLS · 2013Review
- The -149C>T polymorphism of DNMT3B is not associated with colorectal cancer risk: Evidence from a meta-analysis based on case-control studies.Experimental and therapeutic medicine · 2012Article
- Genetic variation in the promoter of DNMT3B is associated with the risk of colorectal cancer.International journal of colorectal disease · 2011Article
- DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011Article
- Two-stage case-control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk.Breast cancer research and treatment · 2010Article
- Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma.Molecular biology reports · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis. Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation in several cancers, thereby modulating the susceptibility to cancer.
methodsDNMT3B -579G>T genotypes and -149C>T were determined by PCR-RFLP and sequencing in 137 colorectal cancer patients and 308 controls matched for age and sex, who did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed colorectal cancer. The association between two SNPs of the DNMT3B promoter and the risk of the development of colorectal cancer was analyzed in a population of Chinese.
resultsThe allele frequency of -149C >T among patients and controls was 0.73% versus 0.65%, respectively. The allele frequency of -597G>T for patients and controls was 6.57% versus 11.53%, respectively. Individuals with at least one -149C>T allele were no at a significantly increase risk of colorectal cancer compared with those having a -149TT genotype. However, Individuals with at least one 579G>T allele were decreased risk of colorectal cancer compared with those having a -579TT genotype.
conclusionThe relative distribution of -149C>T DNMT3B SNPs among a Chinese population can not be used as a stratification marker to predict an individual's susceptibility to colorectal cancer. However, the DNMT3B -579G>T polymorphism may contribute to the genetic susceptibility to colorectal cancer.
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