Evidence map›Paper›PMID 18662293›Full record

ReviewBritish journal of clinical pharmacology2008

Hormesis and medicine.

Edward J Calabrese

Open access · bronzeAbstract readReview
In one paragraph

Review in British journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 256 citations in OpenAlex.

  1. Nutrients · 2019
    Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Ethanol Hormesis in Honeybees (Animals : an open access journal from MDPI · 2025
    Article
  10. Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025
    Review
  11. Review
  12. Mitragynine and morphine produce dose-dependent bimodal action on food but not water intake in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. International journal of molecular sciences · 2023
    Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Edward J CalabreseDepartment of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA. edwardc@schoolph.umass.edu
University of Massachusetts Amherst · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence is presented which supports the conclusion that the hormetic dose-response model is the most common and fundamental in the biological and biomedical sciences, being highly generalizable across biological model, endpoint measured and chemical class and physical agent. The paper provides a broad spectrum of applications of the hormesis concept for clinical medicine including anxiety, seizure, memory, stroke, cancer chemotherapy, dermatological processes such as hair growth, osteoporosis, ocular diseases, including retinal detachment, statin effects on cardiovascular function and tumour development, benign prostate enlargement, male sexual behaviours/dysfunctions, and prion diseases.

Indexed as

Dose-Response Relationship, DrugAnimalsHumansLethal Dose 50No-Observed-Adverse-Effect LevelPharmacology, ClinicalToxicology

Identifiers

PMID18662293
PMCPMC2661975
OpenAlexW1982656090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.