ArticleWorld journal of pediatrics : WJP2008
Expression of T subsets and mIL-2R in peripheral blood of newborns with hypoxic ischemic encephalopathy.
Article in World journal of pediatrics : WJP, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Neuroimmune responses in neonatal hypoxic-ischemic encephalopathy: cellular roles, crosstalk, and therapeutic opportunities.Frontiers in pediatrics · 2026Review
- Preconditioning and Posttreatment Strategies in Neonatal Hypoxic-Ischemic Encephalopathy: Recent Advances and Clinical Challenges.Molecular neurobiology · 2025Review
- Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy.Frontiers in molecular neuroscience · 2019Review
- Brain-immune interactions in perinatal hypoxic-ischemic brain injury.Progress in neurobiology · 2017Review
- Flow Cytometric Characterization of T Cell Subsets and Microglia After Repetitive Mild Traumatic Brain Injury in Rats.Neurochemical research · 2017Article
- Sex differences in stroke across the lifespan: The role of T lymphocytes.Neurochemistry international · 2017Review
- Oxidative Stress in Hypoxic-Ischemic Encephalopathy: Molecular Mechanisms and Therapeutic Strategies.International journal of molecular sciences · 2016Review
- Plasticity in the Neonatal Brain following Hypoxic-Ischaemic Injury.Neural plasticity · 2016Review
- Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage.Frontiers in immunology · 2015Review
- Inflammatory responses in hypoxic ischemic encephalopathy.Acta pharmacologica Sinica · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfantile and undifferentiated immune cells in the pathogenesis of neonates with HIE have been studied in recent years. This study was undertaken to observe the expression level of T subsets and membrane interleukin-2 receptor (mIL-2R) in the peripheral blood of newborns with hypoxic ischemic encephalopathy (HIE) and its clinical manifestations.
methodsThe peripheral blood mononuclear cells (PBMCs) of newborns with HIE and normal controls were isolated by the routine Ficoll-Hypaque method, and the rates of CD3+, CD4+, CD8+, CD4+/CD8+ and mIL-2R induced and not induced by phytohemagglutinin (PHA) were detected by biotin-streptavidin (BSA) at the first, third and seventh day after birth.
resultsAt the first day after birth, the positive rates of CD3+, CD4+, CD8+, CD4+/CD8+ and mIL-2R induced and not induced by PHA were (37.4+/-6.7)%, (29.4+/-6.9)%, (16.7+/-3.3)%, 1.8+/-0.5, (3.6+/-1.1)% and (20.9+/-4.8)%, respectively. Significant differences were observed between the HIE group and the normal controls (P<0.01-P<0.05). At the third day after birth, the positive rates of CD3+, CD4+, CD8+, CD4+/CD*+ and mIL-2R induced and not induced by PHA were (41.0+/-7.4)%, (35.8+/-6.9)%, (22.6+/-4.5)%, (1.7+/-0.5), (3.9+/-1.2)%, and (22.8+/-5.1)%, respectively. There were significant differences between the HIE group and the normal controls (P<0.05). At the seventh day after birth, the positive rates of CD3+, CD4+, CD8+ were (41.8+/-6.1)%, (36.4+/-5.1)% and (25.6+/-4.3)%, respectively. There was significant difference between the HIE group and the normal controls (P<0.05). The ratio of CD4+/CD8+ and the expression level of mIL-2R induced and not induced by PHA were 1.5+/-0.3, (4.1+/-1.2)% and (23.8+/-5.2)%, respectively. There was no significant difference between the HIE group and the normal controls (P>0.05).
conclusionsPeripheral blood mononuclear cells of newborns are immature and undifferentiated with a very low expression level of surface markers. The changes of cell immunity involve in the pathogenesis of HIE. The disorder of cellular immune function exists in newborns with HIE. Cell immunity and immune regulative response in newborns are gradually improved or mature during the period of growing, facilitating the recovery from brain injury caused by HIE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.