ArticleJapanese journal of ophthalmology
Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Müller cells.
Article in Japanese journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Noninvasive electrical stimulation as a neuroprotective strategy in retinal diseases: a systematic review of preclinical studies.Journal of translational medicine · 2024Pooled it
- Transcorneal electrical stimulation: impact on healthcare and future potential.Frontiers in cell and developmental biology · 2025Review
- Glial cells as a promising therapeutic target of glaucoma: beyond the IOP.Frontiers in ophthalmology · 2023Review
- A regulatory pathway model of neuropsychological disruption in Havana syndrome.Frontiers in psychiatry · 2023Article
- Degeneration of retina-brain components and connections in glaucoma: Disease causation and treatment options for eyesight preservation.Current research in neurobiology · 2022Review
- Neuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression.Cells · 2021Review
- LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells.Scientific reports · 2021Article
- Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases.BioMed research international · 2021Review
- A Single-Arm, Prospective, Exploratory Study to Preliminarily Test Effectiveness and Safety of Skin Electrical Stimulation for Leber Hereditary Optic Neuropathy.Journal of clinical medicine · 2020Article
- Noninvasive Electrical Stimulation Improves Photoreceptor Survival and Retinal Function in Mice with Inherited Photoreceptor Degeneration.Investigative ophthalmology & visual science · 2020Article
- Electrical Stimulation Induces Retinal Müller Cell Proliferation and Their Progenitor Cell Potential.Cells · 2020Article
- The Effects of an Ocular Direct Electrical Stimulation on Pattern-Reversal Electroretinogram.Frontiers in neuroscience · 2020Article
- Target-Derived Neurotrophic Factor Deprivation Puts Retinal Ganglion Cells on Death Row: Cold Hard Evidence and Caveats.International journal of molecular sciences · 2019Review
- Pulsed Electrical Stimulation of the Human Eye Enhances Retinal Vessel Reaction to Flickering Light.Frontiers in human neuroscience · 2019Article
- Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury.Scientific reports · 2018Article
- Neuroprotective strategies for retinal disease.Progress in retinal and eye research · 2018Review
- Non-invasive electrical brain stimulation: from acute to late-stage treatment of central nervous system damage.Neural regeneration research · 2017Review
- Using Electrical Stimulation to Enhance the Efficacy of Cell Transplantation Therapies for Neurodegenerative Retinal Diseases: Concepts, Challenges, and Future Perspectives.Cell transplantation · 2017Review
- Electrical Stimulation as a Means for Improving Vision.The American journal of pathology · 2016Review
- Whole-eye electrical stimulation therapy preserves visual function and structure in P23H-1 rats.Experimental eye research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of electrical stimulation (ES) on the induction of insulin-like growth factor 1 (IGF-1) in cultured retinal Müller cells.
methodsMüller cells were isolated from rat retinas. ES was applied to Müller cells of passage 1 with biphasic pulses (duration, 1 ms; frequency, 20 Hz; current, 0-10 mA) for 30 min. The mRNA level of IGF-1 was determined by reverse transcription-polymerase chain reaction (RT-PCR) immediately to 2 h after ES. The change of intracellular calcium concentration ([Ca(2+)]) induced by ES was monitored by Ca(2+) imaging with Fura 2-AM. Ca(2+) imaging and RT-PCR were performed with and without the application of l muM nifedipine, an L-type calcium channel blocker.
resultsThe mRNA level of IGF-1 was increased significantly (P<0.05) by about 1.3-fold immediately after 10 mA ES. [Ca(2+)] began to increase immediately after the start of ES, reached a maximum of approximately 1.8-fold, and continued to increase until about 20 min after the ES. The inductions of IGF-1 transcription and Ca(2+) influx were suppressed by nifedipine.
conclusionsThese results indicate that the enhancement of IGF-1 transcription by ES in cultured Müller cells depends largely on Ca(2+) influx through L-type Ca(2+) channels.
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