Evidence map›Paper›PMID 18661248›Full record

ArticleInternational urology and nephrology2008

Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.

Rodrigo Alves de Oliveira, Lílian Magalhães Fechine, Francisco Costa Neto, José Marcílio Nicodemus, Geraldo B Silva, Leila S V Silva

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Posterior reversible encephalopathy syndrome-an under recognized manifestation of Chronic Kidney Disease.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2013
    Article
  11. Neurotoxicity associated with cancer therapy.Journal of the advanced practitioner in oncology · 2012
    Review
  12. Article
  13. Case files of the New York City poison control center: paradichlorobenzene-induced leukoencephalopathy.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rodrigo Alves de OliveiraDivision of Nephrology, School of Medicine, Universidade Federal do Ceará, Barbalha, Ceara, Brazil. rodrigoalves@ufc.br
Lílian Magalhães Fechine
Francisco Costa Neto
José Marcílio Nicodemus
Geraldo B Silva
Leila S V Silva
Universidade Federal do Ceará · BRUniversidade Federal do Cariri · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPosterior reversible encephalopathy syndrome (PRES) is characterized by abnormalities in cerebral white matter and neurologic symptoms. It can be caused by immunosuppressive drugs or autoimmune diseases. We describe a case of PRES in a patient with collapsing focal glomeruloesclerosis (collapsing FGS) with complete recovery after withdrawal of cyclosporine (CSA). CASE REPORT: A 27-year-old male presented a corticosteroid-resistant nephrotic syndrome secondary to collapsing FGS corticosteroid. Treatment with CSA was started after a nonresponding course of prednisone. Three weeks later, he developed an abrupt elevation of blood pressure (210/120 mmHg), with headaches, mental confusion, and generalized seizures. Magnetic resonance imaging (MRI) showed lesions suggestive of PRES. CSA was withdrawn, and a new MRI was normal after 2 months.

conclusionsPRES is a rare syndrome that must be suspected in every patient presenting neurologic symptoms in the course of immunosuppression. It can be induced by CSA and is totally reversible when the drug is rapidly withdrawn.

Indexed as

AdultCyclosporineGlomerulosclerosis, Focal SegmentalHumansImmunosuppressive AgentsMagnetic Resonance ImagingMalePosterior Leukoencephalopathy SyndromeCyclosporineImmunosuppressive Agents

Identifiers

PMID18661248
OpenAlexW2013697241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.