ReviewYearbook of medical informatics2008
Accessing and integrating data and knowledge for biomedical research.
Review in Yearbook of medical informatics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Targeting Streptomyces-Derived Streptenol Derivatives against Gynecological Cancer Target PIK3CA: An In Silico Approach.BioMed research international · 2022Article
- Statistical Enrichment Analysis of Samples: A General-Purpose Tool to Annotate Metadata Neighborhoods of Biological Samples.Frontiers in big data · 2021Article
- Integrative Base Ontology for the Research Analysis of Alzheimer's Disease-Related Mild Cognitive Impairment.Frontiers in neuroinformatics · 2021Article
- Examining Tensions That Affect the Evaluation of Technology in Health Care: Considerations for System Decision Makers From the Perspective of Industry and Evaluators.JMIR medical informatics · 2017Article
- Preprocessing structured clinical data for predictive modeling and decision support. A roadmap to tackle the challenges.Applied clinical informatics · 2016Article
- Immune modulators in disease: integrating knowledge from the biomedical literature and gene expression.Journal of the American Medical Informatics Association : JAMIA · 2016Article
- Resolving complex research data management issues in biomedical laboratories: Qualitative study of an industry-academia collaboration.Computer methods and programs in biomedicine · 2016Article
- The Analytic Information Warehouse (AIW): a platform for analytics using electronic health record data.Journal of biomedical informatics · 2013Article
- BioUSeR: a semantic-based tool for retrieving Life Science web resources driven by text-rich user requirements.Journal of biomedical semantics · 2013Article
- Linked data and online classifications to organise mined patterns in patient data.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2013Article
- Machine learning and data mining: strategies for hypothesis generation.Molecular psychiatry · 2012Article
- Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers.Journal of medicinal chemistry · 2012Article
- The layer-oriented approach to declarative languages for biological modeling.PLoS computational biology · 2012Article
- The TOKEn project: knowledge synthesis for in silico science.Journal of the American Medical Informatics Association : JAMIA · 2011Article
- The BioLexicon: a large-scale terminological resource for biomedical text mining.BMC bioinformatics · 2011Article
- Japanese EMRs and IT in Medicine: Expansion, Integration, and Reuse of Data.Healthcare informatics research · 2011Article
- TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery.PloS one · 2011Article
- NeuroLOG: sharing neuroimaging data using an ontology-based federated approach.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2011Article
- Data analysis and data mining: current issues in biomedical informatics.Methods of information in medicine · 2011Article
- Integrating heterogeneous knowledge sources to acquire executable drug-related knowledge.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectivesTo review the issues that have arisen with the advent of translational research in terms of integration of data and knowledge, and survey current efforts to address these issues.
methodsUsing examples form the biomedical literature, we identified new trends in biomedical research and their impact on bioinformatics. We analyzed the requirements for effective knowledge repositories and studied issues in the integration of biomedical knowledge.
resultsNew diagnostic and therapeutic approaches based on gene expression patterns have brought about new issues in the statistical analysis of data, and new workflows are needed are needed to support translational research. Interoperable data repositories based on standard annotations, infrastructures and services are needed to support the pooling and meta-analysis of data, as well as their comparison to earlier experiments. High-quality, integrated ontologies and knowledge bases serve as a source of prior knowledge used in combination with traditional data mining techniques and contribute to the development of more effective data analysis strategies.
conclusionAs biomedical research evolves from traditional clinical and biological investigations towards omics sciences and translational research, specific needs have emerged, including integrating data collected in research studies with patient clinical data, linking omics knowledge with medical knowledge, modeling the molecular basis of diseases, and developing tools that support in-depth analysis of research data. As such, translational research illustrates the need to bridge the gap between bioinformatics and medical informatics, and opens new avenues for biomedical informatics research.
Indexed as
Identifiers
18660883PMC2553094What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.