ArticleNature genetics2008
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi.
Article in Nature genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 303 papers, 2 of them syntheses that pooled it.
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Who cites it
303 citing papers in PubMed, 2 syntheses or guidelines pooled it, 518 citations in OpenAlex.
- Pooled it
- A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.PLoS neglected tropical diseases · 2018Pooled it
- Trial
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- The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.Communications biology · 2024Article
243 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 7 institutions in 5 countries.
Funding
Abstract
Isolates of Salmonella enterica serovar Typhi (Typhi), a human-restricted bacterial pathogen that causes typhoid, show limited genetic variation. We generated whole-genome sequences for 19 Typhi isolates using 454 (Roche) and Solexa (Illumina) technologies. Isolates, including the previously sequenced CT18 and Ty2 isolates, were selected to represent major nodes in the phylogenetic tree. Comparative analysis showed little evidence of purifying selection, antigenic variation or recombination between isolates. Rather, evolution in the Typhi population seems to be characterized by ongoing loss of gene function, consistent with a small effective population size. The lack of evidence for antigenic variation driven by immune selection is in contrast to strong adaptive selection for mutations conferring antibiotic resistance in Typhi. The observed patterns of genetic isolation and drift are consistent with the proposed key role of asymptomatic carriers of Typhi as the main reservoir of this pathogen, highlighting the need for identification and treatment of carriers.
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