ArticleNature neuroscience2008
Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans.
Article in Nature neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
113 citing papers in PubMed, 201 citations in OpenAlex.
- A repressive regulatory cascade shapes temporal patterning of activity-regulated gene expression in a defined sensory neuron type.bioRxiv : the preprint server for biology · 2026Article
- Experience-Dependent Gain Modulation Drives Thermosensory Responses in Behavior.bioRxiv : the preprint server for biology · 2026Article
- Article
- Activity induced GEM-4/Copine expression inhibits gap junctions and promotes thermosensory plasticity.bioRxiv : the preprint server for biology · 2026Article
- Experience-dependent reconfiguration of thermoreceptors regulates neuronal response plasticity.Current biology : CB · 2026Article
- A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation.Nature communications · 2026Article
- Article
- A multilayered gap junction network is essential for social decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Configuration of electrical synapses filters sensory information to drive behavioral choices.Cell · 2025Article
- Aberrant neuronal hyperactivation causes an age-dependent behavioral decline inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells.PLoS computational biology · 2025Article
- An integrative data-driven model simulating C. elegans brain, body and environment interactions.Nature computational science · 2024Article
- Identification of BiP as a temperature sensor mediating temperature-induced germline sex reversal in C. elegans.The EMBO journal · 2024Article
- Advanced Neural Functional Imaging inMicromachines · 2024Review
- A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A tonically active master neuron modulates mutually exclusive motor states at two timescales.Science advances · 2024Article
- Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A standard workflow for community-driven manual curation ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans.Nature communications · 2024Article
- Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families.PloS one · 2024Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Humans and other animals can sense temperature changes as small as 0.1 degree C. How animals achieve such exquisite sensitivity is poorly understood. By recording from the C. elegans thermosensory neurons AFD in vivo, we found that cooling closes and warming opens ion channels. We found that AFD thermosensitivity, which exceeds that of most biological processes by many orders of magnitude, is achieved by nonlinear signal amplification. Mutations in genes encoding subunits of a cyclic guanosine monophosphate (cGMP)-gated ion channel (tax-4 and tax-2) and transmembrane guanylate cyclases (gcy-8, gcy-18 and gcy-23) eliminated both cooling- and warming-activated thermoreceptor currents, indicating that a cGMP-mediated pathway links variations in temperature to changes in ionic currents. The resemblance of C. elegans thermosensation to vertebrate photosensation and the sequence similarity between TAX-4 and TAX-2 and subunits of the rod phototransduction channel raise the possibility that nematode thermosensation and vertebrate vision are linked by conserved evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.