ReviewCurrent opinion in nephrology and hypertension2008
The noncalciotropic actions of vitamin D: recent clinical developments.
Review in Current opinion in nephrology and hypertension, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01991054 (A Prospective, Double Blind, Randomized, Phase 4, Clinical Trial of The Effects of Vitamin D Supplementation on Patients With Type 2 Diabetes and Vitamin D Deficiency), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Double Blind, Randomized, Phase 4, Clinical Trial of The Effects of Vitamin D Supplementation on Patients With Type 2 Diabetes and Vitamin D Deficiency
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Impact of vitamin D replacement in adults and elderly in the Middle East and North Africa: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial.Journal of the American Geriatrics Society · 2016Trial
- Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials.Scandinavian journal of infectious diseases · 2012Trial
- Vitamin D Status and Health Outcomes in School Children in Northern Ireland: Year One Results from the D-VinCHI Study.Nutrients · 2022Article
- Adequate 25-hydroxyvitamin D levels are inversely associated with various cardiometabolic risk factors in Chinese children, especially obese children.BMJ open diabetes research & care · 2020Article
- Evaluation of Serum Vitamin D Levels in Diabetic Foot Infections: A Cross-Sectional Study in a Tertiary Care Center in South India.Iranian journal of medical sciences · 2019Article
- Association between vitamin D deficiency and lipid and non-lipid markers of cardiovascular diseases in the middle east region.European journal of clinical nutrition · 2019Article
- Lactase persistence may explain the paradoxical findings of high vitamin D concentrations in Europeans living in areas of low UV-B irradiation.European journal of clinical nutrition · 2019Article
- Link between community-acquired pneumonia and vitamin D levels in older patients.Zeitschrift fur Gerontologie und Geriatrie · 2018Article
- Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions.International journal of molecular sciences · 2017Article
- Longitudinal changes in serum 25-hydroxyvitamin D in the Dallas Heart Study.Clinical endocrinology · 2017Article
- Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants.Medicine · 2015Article
- Changes of 25-OH-Vitamin D during Overwintering at the German Antarctic Stations Neumayer II and III.PloS one · 2015Article
- Vitamin D deficiency impacts on expression of toll-like receptor-2 and cytokine profile: a pilot study.Journal of translational medicine · 2013Article
- The immunoregulatory function of vitamin D: implications in chronic kidney disease.Nature reviews. Nephrology · 2012Review
- Vitamin D deficiency in HIV-infected and HIV-uninfected women in the United States.Journal of acquired immune deficiency syndromes (1999) · 2011Article
- Vitamin d, and kidney disease.Electrolyte & blood pressure : E & BP · 2011Article
- Review
- Vitamin d and serum cytokines in a randomized clinical trial.International journal of endocrinology · 2010Article
- Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the Women's Interagency HIV Study of HIV-infected and uninfected women in the United States.Journal of the International Association of Providers of AIDS CareObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis review summarizes recently described actions of 1,25-dihydroxyvitamin D beyond its function in calcium homeostasis and bone metabolism. RECENT
findings1,25-Dihydroxyvitamin D stimulates the innate immune system, facilitating the clearance of infections such as tuberculosis. Hypovitaminosis D has been associated with several autoimmune disorders, various malignancies, and cardiovascular risk factors in a number of recent epidemiologic reports. Based on these observational reports, vitamin D and its analogues are being evaluated for the prevention and treatment of a variety of conditions, with early findings showing mixed results. SUMMARY: The broad tissue distribution of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme and the vitamin D receptor establish a role for 1,25-dihydroxyvitamin D in the pathophysiology of various disease states and provide new therapeutic targets for vitamin D and its analogues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.