ArticleGenetics2008
Within-generation mutation variance for litter size in inbred mice.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection.PLoS biology · 2024Article
- Towards mouse genetic-specific RNA-sequencing read mapping.PLoS computational biology · 2022Article
- The contribution of mutation and selection to multivariate quantitative genetic variance in an outbred population ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Discovering lethal alleles across the turkey genome using a transmission ratio distortion approach.Animal genetics · 2020Article
- Article
- Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans.Open biology · 2016Article
- Simultaneous Estimation of Additive and Mutational Genetic Variance in an Outbred Population of Drosophila serrata.Genetics · 2015Article
- Bayesian analysis of additive epistasis arising from new mutations in mice.Genetics research · 2014Article
- Article
- Evidence of maternal QTL affecting growth and obesity in adult mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Segregation analysis of a sex ratio distortion locus in congenic mice.The Journal of heredityArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mutational input of genetic variance per generation (sigma(m)(2)) is the lower limit of the genetic variability in inbred strains of mice, although greater values could be expected due to the accumulation of new mutations in successive generations. A mixed-model analysis using Bayesian methods was applied to estimate sigma(m)(2) and the across-generation accumulated genetic variability on litter size in 46 generations of a C57BL/6J inbred strain. This allowed for a separate inference on sigma(m)(2) and on the additive genetic variance in the base population (sigma(a)(2)). The additive genetic variance in the base generation was 0.151 and quickly decreased to almost null estimates in generation 10. On the other hand, sigma(m)(2) was moderate (0.035) and the within-generation mutational variance increased up to generation 14, then oscillating between 0.102 and 0.234 in remaining generations. This pattern suggested the existence of a continuous uploading of genetic variability for litter size (h(2)=0.045). Relevant genetic drift was not detected in this population. In conclusion, our approach allowed for separate estimation of sigma(a)(2) and sigma(m)(2) within the mixed-model framework, and the heritability obtained highlighted the significant and continuous influence of new genetic variability affecting the genetic stability of inbred strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.