ArticleNucleic acids research2008
Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Association betweenThe Journal of international medical research · 2022Pooled it
- Pooled it
- Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway.Molecular biology reports · 2022Review
- Case-control study on TP73 rs1801173 C > T gene polymorphism and susceptibility to gastric cancer in a Chinese Han population.BMC medical genomics · 2022Article
- Characterization and Validation of ceRNA-Mediated Pathway-Pathway Crosstalk Networks Across Eight Major Cardiovascular Diseases.Frontiers in cell and developmental biology · 2022Article
- The p53 family member p73 in the regulation of cell stress response.Biology direct · 2021Review
- Review
- Article
- The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.Cold Spring Harbor perspectives in medicine · 2016Review
- Quantitative and logic modelling of molecular and gene networks.Nature reviews. Genetics · 2015Review
- Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs.International journal of molecular sciences · 2014Article
- Dipeptide analysis of p53 mutations and evolution of p53 family proteins.Biochimica et biophysica acta · 2014Article
- Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance.Cell cycle (Georgetown, Tex.) · 2012Article
- A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma.Oncotarget · 2011Article
- Common genetic variants in cell cycle pathway are associated with survival in stage III-IV non-small-cell lung cancer.Carcinogenesis · 2011Article
- A formal MIM specification and tools for the common exchange of MIM diagrams: an XML-Based format, an API, and a validation method.BMC bioinformatics · 2011Article
- Article
- The origins and evolution of the p53 family of genes.Cold Spring Harbor perspectives in biology · 2010Review
- Mechanisms of transcription factor selectivity.Trends in genetics : TIG · 2010Review
- Protein-protein interaction networks: how can a hub protein bind so many different partners?Trends in biochemical sciences · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have compiled the p73-mediated cell cycle arrest and apoptosis pathways. p73 is a member of the p53 family, consisting of p53, p63 and p73. p73 exists in several isoforms, presenting different domain structures. p73 functions not only as a tumor suppressor in apoptosis but also as differentiator in embryo development. p53 mutations are responsible for half of the human cancers; p73 can partially substitute mutant p53 as tumor suppressor. The pathways we assembled create a p73-centered network consisting of 53 proteins and 176 interactions. We clustered our network into five functional categories: Upregulation, Activation, Suppression, Transcriptional Activity and Degradation. Our literature searches led to discovering proteins (c-Jun and pRb) with apparent opposing functional effects; these indicate either currently missing proteins and interactions or experimental misidentification or functional annotation. For convenience, here we present the p73 network using the molecular interaction map (MIM) notation. The p73 MIM is unique amongst MIMs, since it further implements detailed domain features. We highlight shared pathways between p53 and p73. We expect that the compiled and organized network would be useful to p53 family-based studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.