ArticleAmerican journal of physiology. Heart and circulatory physiology2008
Roles of cell and microvillus deformation and receptor-ligand binding kinetics in cell rolling.
Article in American journal of physiology. Heart and circulatory physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Combined TIRF and 3D Super-Resolution Microscopy for Nanoscopic Characterization of Adhesion Molecules on Microvilli.Analytical chemistry · 2026Article
- Computational study of cell adhesion and rolling in flow channel by meshfree method.Computer methods in biomechanics and biomedical engineering · 2017Article
- Multi-scale biological and physical modelling of the tumour micro-environment.Drug discovery today. Disease models · 2015Article
- Article
- Yielding elastic tethers stabilize robust cell adhesion.PLoS computational biology · 2014Article
- Neutrophil rolling at high shear: flattening, catch bond behavior, tethers and slings.Molecular immunology · 2013Review
- Effect of extracellular pH on selectin adhesion: theory and experiment.Biophysical journal · 2013Article
- Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries.PLoS computational biology · 2013Article
- A low-dimensional deformation model for cancer cells in flow.Physics of fluids (Woodbury, N.Y. : 1994) · 2012Article
- Effect of loading conditions on the dissociation behaviour of catch bond clusters.Journal of the Royal Society, Interface · 2012Article
- Study of local hydrodynamic environment in cell-substrate adhesion using side-view μPIV technology.PloS one · 2012Article
- Cell protrusions and tethers: a unified approach.Biophysical journal · 2011Article
- Biomechanics of leukocyte rolling.Biorheology · 2011Review
- A semianalytical model to study the effect of cortical tension on cell rolling.Biophysical journal · 2010Article
- Shear-stabilized rolling behavior of E. coli examined with simulations.Biophysical journal · 2010Article
- Linear diode laser bar optical stretchers for cell deformation.Biomedical optics express · 2010Article
- Dynamic ray tracing for modeling optical cell manipulation.Optics express · 2010Article
- Adhesive dynamics simulations of the mechanical shedding of L-selectin from the neutrophil surface.Journal of theoretical biology · 2009Article
- Dynamics of Microvillus Extension and Tether Formation in Rolling Leukocytes.Cellular and molecular bioengineering · 2009Article
- Cell deformation cytometry using diode-bar optical stretchers.Journal of biomedical opticsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Polymorphonuclear leukocyte (PMN) recruitment to sites of inflammation is initiated by selectin-mediated PMN tethering and rolling on activated endothelium under flow. Cell rolling is modulated by bulk cell deformation (mesoscale), microvillus deformability (microscale), and receptor-ligand binding kinetics (nanoscale). Selectin-ligand bonds exhibit a catch-slip bond behavior, and their dissociation is governed not only by the force but also by the force history. Whereas previous theoretical models have studied the significance of these three "length scales" in isolation, how their interplay affects cell rolling has yet to be resolved. We therefore developed a three-dimensional computational model that integrates the aforementioned length scales to delineate their relative contributions to PMN rolling. Our simulations predict that the catch-slip bond behavior and to a lesser extent bulk cell deformation are responsible for the shear threshold phenomenon. Cells bearing deformable rather than rigid microvilli roll slower only at high P-selectin site densities and elevated levels of shear (>or=400 s(-1)). The more compliant cells (membrane stiffness=1.2 dyn/cm) rolled slower than cells with a membrane stiffness of 3.0 dyn/cm at shear rates >50 s(-1). In summary, our model demonstrates that cell rolling over a ligand-coated surface is a highly coordinated process characterized by a complex interplay between forces acting on three distinct length scales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.