ArticlePlant physiology2008
In planta analysis of the cell cycle-dependent localization of AtCDC48A and its critical roles in cell division, expansion, and differentiation.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Cryo-EM structural analyses reveal plant-specific adaptations of the CDC48 unfoldase.Plant communications · 2026Article
- A ubiquitin-GhUBX-GhCDC48 module regulates secondary cell wall thickening in cotton fiber.Plant physiology · 2025Article
- Transcriptomic Analysis of Osmotic Stress-Tolerant Somatic Embryos ofInternational journal of molecular sciences · 2025Article
- Dt1 interacts with HB40 to affect lateral root primordium development by regulating CDC48 in soybean.Plant biotechnology journal · 2025Article
- Modulation of Root Hydrotropism and Recovery From Drought by MIZ1-like Genes in Tomato.Plant, cell & environment · 2025Article
- Dissecting the genetic architecture of key agronomic traits in lettuce using a MAGIC population.Genome biology · 2025Article
- Identification of miRNAs Involved in Lipid Metabolism and Tuber Development inPlants (Basel, Switzerland) · 2024Article
- CDC48A, an interactor of WOX2, is required for embryonic patterning in Arabidopsis thaliana.Plant cell reports · 2024Article
- CmERF1 acts as a positive regulator of fruits and leaves growth in melon (Cucumis melo L.).Plant molecular biology · 2024Article
- A fungal core effector exploits the OsPUX8B.2-OsCDC48-6 module to suppress plant immunity.Nature communications · 2024Article
- GA signaling expands: The plant UBX domain-containing protein 1 is a binding partner for the GA receptor.Plant physiology · 2022Article
- The Shared Proteome of the Apomictic FernInternational journal of molecular sciences · 2022Article
- Ubiquitome profiling reveals a regulatory pattern of UPL3 with UBP12 on metabolic-leaf senescence.Life science alliance · 2022Article
- Protein-protein interactions in plant antioxidant defense.Frontiers in plant science · 2022Review
- Comparative transcriptome analysis reveals key pathways and genes involved in trichome development in tea plant (Frontiers in plant science · 2022Article
- Transcriptome profiling reveals key genes in regulation of the tepal trichome development in Lilium pumilum D.C.Plant cell reports · 2021Article
- Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins.Computational and structural biotechnology journal · 2021Review
- Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants.Nature communications · 2020Article
- Construction of a high-density genetic map and QTL mapping of leaf traits and plant growth in an interspecific FBMC plant biology · 2019Article
- Sebastian Bednarek.The Plant cell · 2019Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CDC48/p97 is a conserved homohexameric AAA-ATPase chaperone required for a variety of cellular processes but whose role in the development of a multicellular model system has not been examined. Here, we have used reverse genetics, visualization of a functional Arabidopsis (Arabidopsis thaliana) CDC48 fluorescent fusion protein, and morphological analysis to examine the subcellular distribution and requirements for AtCDC48A in planta. Homozygous Atcdc48A T-DNA insertion mutants arrest during seedling development, exhibiting decreased cell expansion and displaying pleiotropic defects in pollen and embryo development. Atcdc48A insertion alleles show significantly reduced male transmission efficiency due to defects in pollen tube growth. Yellow fluorescent protein-AtCDC48A, a fusion protein that functionally complements the insertion mutant defects, localizes in the nucleus and cytoplasm and is recruited to the division mid-zone during cytokinesis. The pattern of nuclear localization differs according to the stage of the cell cycle and differentiation state. Inducible expression of an Atcdc48A Walker A ATPase mutant in planta results in cytokinesis abnormalities, aberrant cell divisions, and root trichoblast differentiation defects apparent in excessive root hair emergence. At the biochemical level, our data suggest that the endogenous steady-state protein level of AtCDC48A is dependent upon the presence of ATPase-active AtCDC48A. These results demonstrate that CDC48A/p97 is critical for cytokinesis, cell expansion, and differentiation in plants.
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