ArticleApplied and environmental microbiology2008
Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 117 citations in OpenAlex.
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- Population-Specific Transcriptomic Shifts Underlie Secondary Metabolic Diversification inbioRxiv : the preprint server for biology · 2025Article
- ZfpA-Dependent Quorum Sensing Shifts in Morphology and Secondary Metabolism in Aspergillus flavus.Environmental microbiology · 2025Article
- Quorum sensing in Saccharomyces cerevisiae brewing strains: effects of 2-phenylethanol on proteomic, lipidomic, and metabolomic profile.FEMS yeast research · 2025Article
- Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway.Cellular and molecular life sciences : CMLS · 2024Article
- Production of hispidin polyphenols from medicinal mushroomChinese herbal medicines · 2023Article
- Weapons against Themselves: Identification and Use of Quorum Sensing Volatile Molecules to Control Plant Pathogenic Fungi Growth.Microorganisms · 2022Article
- A roadmap to understanding diversity and function of coral reef-associated fungi.FEMS microbiology reviews · 2022Article
- Regulator of G Protein Signaling Contributes to the Development and Aflatoxin Biosynthesis in Aspergillus flavus through the Regulation of Gα Activity.Applied and environmental microbiology · 2022Article
- Review
- Fungal and bacterial oxylipins are signals for intra- and inter-cellular communication within plant disease.Frontiers in plant science · 2022Review
- Review
- The Conserved MAP Kinase MpkB Regulates Development and Sporulation without Affecting Aflatoxin Biosynthesis inJournal of fungi (Basel, Switzerland) · 2020Article
- Fungal oxylipins direct programmed developmental switches in filamentous fungi.Nature communications · 2020Article
- Lipo-chitooligosaccharides as regulatory signals of fungal growth and development.Nature communications · 2020Article
- The Lipoxygenase Lox1 Is Involved in Light- and Injury-Response, Conidiation, and Volatile Organic Compound Biosynthesis in the Mycoparasitic FungusFrontiers in microbiology · 2020Article
- Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction.PLoS biology · 2019Article
- Co-opting oxylipin signals in microbial disease.Cellular microbiology · 2019Review
- Fungal Quorum-Sensing Molecules and Inhibitors with Potential Antifungal Activity: A Review.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus flavus differentiates to produce asexual dispersing spores (conidia) or overwintering survival structures called sclerotia. Results described here show that these two processes are oppositely regulated by density-dependent mechanisms and that increasing the cell density (from 10(1) to 10(7) cells/plate) results in the lowest numbers of sclerotial and the highest numbers of conidial. Extract from spent medium of low-cell-density cultures induced a high-sclerotium-number phenotype, whereas high-cell-density extract increased conidiation. Density-dependent development is also modified by changes in lipid availability. Exogenous linoleic acid increased sclerotial production at intermediate cell densities (10(4) and 10(5) cells/plate), whereas oleic and linolenic acids inhibited sclerotium formation. Deletion of Aflox encoding a lipoxygenase (LOX) greatly diminished density-dependent development of both sclerotia and conidia, resulting in an overall increase in the number of sclerotia and a decrease in the number of conidia at high cell densities (>10(5) cells/plate). Aflox mutants showed decreased linoleic acid LOX activity. Taken together, these results suggest that there is a quorum-sensing mechanism in which a factor(s) produced in dense cultures, perhaps a LOX-derived metabolite, activates conidium formation, while a factor(s) produced in low-density cultures stimulates sclerotium formation.
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