ReviewInternational immunology2008
What roles do regulatory T cells play in the control of the adaptive immune response?
Review in International immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Downregulation of sCD40 and sCTLA4 in Recovered COVID-19 Patients with Comorbidities.Pathogens (Basel, Switzerland) · 2022Article
- Diet Associated with Inflammation and Alzheimer's Disease.Journal of Alzheimer's disease reports · 2019Review
- Rationalizing the path to a universal graft recipient.Immunologic research · 2018Review
- Learning from a contemporary history of immunology.Immunologic research · 2017Review
- Analysis of Paris meeting redefining the "self" of the immune system.Immunologic research · 2015Article
- A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells).Cellular and molecular life sciences : CMLS · 2014Review
- Ten experiments that would make a difference in understanding immune mechanisms.Cellular and molecular life sciences : CMLS · 2012Article
- The evolutionary context for a self-nonself discrimination.Cellular and molecular life sciences : CMLS · 2010Article
- Co-inhibitory molecules: Controlling the effectors or controlling the controllers?Self/nonself · 2010Article
- Protease-activated receptors and prostaglandins in inflammatory lung disease.British journal of pharmacology · 2009Review
- How do regulatory T cells work?Scandinavian journal of immunology · 2009Review
- On the critique by Colin Anderson of 'A reply to Dembic: on an end to the beginning of mis-understanding the immune response'.Scandinavian journal of immunology · 2009Article
- On the opposing views of the self-nonself discrimination by the immune system.Immunology and cell biology · 2009Article
- The discussion with Jacques Miller: illustrating the limitations of pure empiricism.Immunology and cell biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The immune system, like many systems responsive to specific stimuli, requires feedback regulation. The key regulatory element determining antigen-specific responsiveness is the effector T helper. As the response tends to overshoot, a feedback control of the magnitude of the response is critical to avoid immunopathology. This is the proposed role of the effector T suppressor (T(s)). The reasons for this interpretation of the data are discussed as are the reasons that the competing postulate is ruled out, namely that T(s) function in determining the self-non-self-discrimination. The regulatory T cell family consists of two lineages, T helpers and T(s). Differentiated derivatives of the T helper lineage drive the expression and amplification of specific classes of defensive effector cells. T(s) feedback to limit the magnitude of the process so that debilitating immunopathology is acceptably infrequent.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.