ArticleRNA (New York, N.Y.)2008
A glimpse into the active site of a group II intron and maybe the spliceosome, too.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The ChloroplastCells · 2021Review
- Visualizing group II intron dynamics between the first and second steps of splicing.Nature communications · 2020Article
- Domestication of self-splicing introns during eukaryogenesis: the rise of the complex spliceosomal machinery.Biology direct · 2017Review
- Stereospecific suppression of active site mutants by methylphosphonate substituted substrates reveals the stereochemical course of site-specific DNA recombination.Nucleic acids research · 2015Article
- Article
- Low selection pressure aids the evolution of cooperative ribozyme mutations in cells.The Journal of biological chemistry · 2013Article
- Now on display: a gallery of group II intron structures at different stages of catalysis.Mobile DNA · 2013Article
- The structural stabilization of the κ three-way junction by Mg(II) represents the first step in the folding of a group II intron.Nucleic acids research · 2013Article
- Role of small nuclear RNAs in eukaryotic gene expression.Essays in biochemistry · 2013Review
- A small ribozyme with dual-site kinase activity.Nucleic acids research · 2012Article
- Biomass production of site selective 13C/15N nucleotides using wild type and a transketolase E. coli mutant for labeling RNA for high resolution NMR.Journal of biomolecular NMR · 2012Article
- Expression, purification and analysis of the activity of enzymes from the pentose phosphate pathway.Protein expression and purification · 2011Article
- The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.Proteomics · 2010Review
- Metal binding and substrate positioning by evolutionarily invariant U6 sequences in catalytically active protein-free snRNAs.RNA (New York, N.Y.) · 2010Article
- The tertiary structure of group II introns: implications for biological function and evolution.Critical reviews in biochemistry and molecular biology · 2010Review
- Probing adenine rings and backbone linkages using base specific isotope-edited Raman spectroscopy: application to group II intron ribozyme domain V.Biochemistry · 2010Article
- Tertiary architecture of the Oceanobacillus iheyensis group II intron.RNA (New York, N.Y.) · 2010Article
- Model systems: how chemical biologists study RNA.Current opinion in chemical biology · 2009Review
- Structural insights into RNA splicing.Current opinion in structural biology · 2009Review
- Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.Molecular bioSystems · 2009Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The X-ray crystal structure of an excised group II self-splicing intron was recently solved by the Pyle group. Here we review some of the notable features of this structure and what they may tell us about the catalytic active site of the group II ribozyme and potentially the spliceosome. The new structure validates the central role of domain V in both the structure and catalytic function of the ribozyme and resolves several outstanding puzzles raised by previous biochemical, genetic and structural studies. While lacking both exons as well as the cleavage sites and nucleophiles, the structure reveals how a network of tertiary interactions can position two divalent metal ions in a configuration that is ideal for catalysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.