ArticleRNA (New York, N.Y.)2008
Noncanonical G(syn)-G(anti) base pairs stabilized by sulphate anions in two X-ray structures of the (GUGGUCUGAUGAGGCC) RNA duplex.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
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- ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.Nucleic acids research · 2022Article
- Berberrubine Phosphate: A Selective Fluorescent Probe for Quadruplex DNA.Molecules (Basel, Switzerland) · 2021Article
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- Stabilization of RNA hairpins using non-nucleotide linkers and circularization.Nucleic acids research · 2017Article
- m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs.Nature structural & molecular biology · 2016Article
- The crystal structure of an oligo(U):pre-mRNA duplex from a trypanosome RNA editing substrate.RNA (New York, N.Y.) · 2011Article
- Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome.Nucleic acids research · 2011Article
- A mutate-and-map strategy accurately infers the base pairs of a 35-nucleotide model RNA.RNA (New York, N.Y.) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structures of two crystal forms of the RNA 16-mer with the sequence GUGGUCUGAUGAGGCC, grown in the presence of a high concentration of sulphate ions, have been determined using synchrotron radiation at 1.4- and 2.0-A resolution. RNA with this sequence is known as one of the two strands of the noncleavable form of the hammerhead ribozyme. In both crystal structures, two G(syn)-G(anti) noncanonical base pairs are observed in the middle of a 14 base-pair (bp) duplex having 5'-dangling GU residues. Both structures contain sulphate anions interacting with the G-G bp stabilizing G in its syn conformation and bridging the two RNA strands. In both cases the interactions take place in the major groove, although the anions are accommodated within different helix geometries, most pronounced in the changing width of the major groove. In one structure, where a single sulphate spans both G-G pairs, the major groove is closed around the anion, while in the other structure, where each of the two G-G pairs is associated with a separate sulphate, the groove is open. This work provides the first examples of a G-G pair in syn-anti conformation, which minimizes the purine-purine clash in the center of the duplex, while utilizing its residual hydrogen bonding potential in specific interactions with sulphate anions.
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