Trial reportBiological psychiatry2008
Elevated neuroimmune biomarkers in sweat patches and plasma of premenopausal women with major depressive disorder in remission: the POWER study.
Trial report in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.
- Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis.Molecular psychiatry · 2018Pooled it
- No effect of tattoos on local sweat concentrations of select cytokines, cortisol, glucose, blood urea nitrogen, or lactate during exercise.Scientific reports · 2024Trial
- Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females.Scientific reports · 2021Trial
- Using sweat to measure cytokines in older adults compared to younger adults: A pilot study.Journal of immunological methods · 2018Trial
- Age-dependent increase in peripheral neuropeptide Y with no cross-sectional link to depression.Acta neuropsychiatrica · 2026Article
- Noninvasive On-Skin Biosensors for Monitoring Diabetes Mellitus.Nano-micro letters · 2025Review
- Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis.Brain, behavior, & immunity - health · 2025Review
- An Updated Bio-Behavioral Profile of the Flinders Sensitive Line Rat: Reviewing the Findings of the Past Decade.Pharmacology research & perspectives · 2025Review
- Detection of Injury Biomarkers in Sweat of Collegiate Athletes Pre- and Post-Football Season: A Pilot Study.Neurotrauma reports · 2025Article
- Microparticles in Human Perspiration as an Inflammatory Response Index.Diagnostics (Basel, Switzerland) · 2024Article
- The challenges and promise of sweat sensing.Nature biotechnology · 2024Review
- Longitudinal assessment of sweat-based TNF-alpha in inflammatory bowel disease using a wearable device.Scientific reports · 2024Article
- Longitudinal monitoring of IL-6 and CRP in inflammatory bowel disease using IBD-AWARE.Biosensors & bioelectronics: X · 2024Article
- Understanding the Biological Relationship between Migraine and Depression.Biomolecules · 2024Review
- Field effect transistor based wearable biosensors for healthcare monitoring.Journal of nanobiotechnology · 2023Review
- Regional and time course differences in sweat cortisol, glucose, and select cytokine concentrations during exercise.European journal of applied physiology · 2023Article
- Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis.Molecules (Basel, Switzerland) · 2023Review
- Biomolecular sensors for advanced physiological monitoring.Nature reviews bioengineering · 2023Review
- Skin-Interfaced Wearable Sweat Sensors for Precision Medicine.Chemical reviews · 2023Review
- Wearable and flexible electrochemical sensors for sweat analysis: a review.Microsystems & nanoengineering · 2023Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is inconsistently associated with elevations in proinflammatory cytokines and neuropeptides. We used a skin sweat patch, recently validated in healthy control subjects, and recycling immunoaffinity chromatography to measure neuroimmune biomarkers in patients with MDD mostly in remission.
methodsWe collected blood at 8:00 am and applied skin sweat patches for 24 hours in 21- to 45-year-old premenopausal women (n = 19) with MDD (17/19 in remission) and age-matched healthy controls (n = 17) participating in the POWER (Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression) Study.
resultsProinflammatory cytokines, neuropeptide Y, substance P, and calcitonin-gene-related peptide were significantly higher and vasoactive intestinal peptide, a marker of parasympathetic activity, was significantly lower in patients compared to controls, and depressive symptomatology strongly correlated with biomarker levels. All analytes were strongly correlated in the skin sweat patch and plasma in patients (r = .73 to .99; p < .0004).
conclusionsThe skin sweat patch allows detection of disrupted patterns of proinflammatory cytokines and neuropeptides in women with MDD in clinical remission, which could predispose to medical consequences such as cardiovascular disease, osteoporosis, and diabetes. This method permits measurement of cytokines in ambulatory settings where blood collection is not feasible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.