ArticleBMC biology2008
Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals.
Article in BMC biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 52 citations in OpenAlex.
- Hemoglobin-Gene Cluster Deletions in Antarctic White-Blooded Icefishes Facilitated by Transposable Elements.Genome biology and evolution · 2025Article
- Unearthing the secrets of Australia's most enigmatic and cryptic mammal, the marsupial mole.Science advances · 2025Article
- Co-Regulated Genes and Gene Clusters.Genes · 2021Review
- Evolution of hemoglobin loci and their regulatory elements.Blood cells, molecules & diseases · 2018Review
- Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates.Genome biology and evolution · 2018Article
- Evolution and Expression of Tissue Globins in Ray-Finned Fishes.Genome biology and evolution · 2017Article
- Convergent evolution of hemoglobin switching in jawed and jawless vertebrates.BMC evolutionary biology · 2016Article
- Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression.Molecular biology and evolution · 2015Article
- Article
- Gene duplication, genome duplication, and the functional diversification of vertebrate globins.Molecular phylogenetics and evolution · 2013Review
- Whole-genome duplication and the functional diversification of teleost fish hemoglobins.Molecular biology and evolution · 2013Article
- Evolution of hemoglobin and its genes.Cold Spring Harbor perspectives in medicine · 2012Article
- Whole-genome duplications spurred the functional diversification of the globin gene superfamily in vertebrates.Molecular biology and evolution · 2012Article
- Phylogenetic analysis reveals wide distribution of globin X.Biology direct · 2011Article
- Oxygen supply from the bird's eye perspective: globin E is a respiratory protein in the chicken retina.The Journal of biological chemistry · 2011Article
- Review
- Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensis.The Journal of experimental biology · 2011Article
- Differential loss and retention of cytoglobin, myoglobin, and globin-E during the radiation of vertebrates.Genome biology and evolution · 2011Article
- Globin gene structure in a reptile supports the transpositional model for amniote α- and β-globin gene evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution.BMC evolutionary biology · 2010Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVertebrate alpha (alpha)- and beta (beta)-globin gene families exemplify the way in which genomes evolve to produce functional complexity. From tandem duplication of a single globin locus, the alpha- and beta-globin clusters expanded, and then were separated onto different chromosomes. The previous finding of a fossil beta-globin gene (omega) in the marsupial alpha-cluster, however, suggested that duplication of the alpha-beta cluster onto two chromosomes, followed by lineage-specific gene loss and duplication, produced paralogous alpha- and beta-globin clusters in birds and mammals. Here we analyse genomic data from an egg-laying monotreme mammal, the platypus (Ornithorhynchus anatinus), to explore haemoglobin evolution at the stem of the mammalian radiation.
resultsThe platypus alpha-globin cluster (chromosome 21) contains embryonic and adult alpha- globin genes, a beta-like omega-globin gene, and the GBY globin gene with homology to cytoglobin, arranged as 5'-zeta-zeta'-alphaD-alpha3-alpha2-alpha1-omega-GBY-3'. The platypus beta-globin cluster (chromosome 2) contains single embryonic and adult globin genes arranged as 5'-epsilon-beta-3'. Surprisingly, all of these globin genes were expressed in some adult tissues. Comparison of flanking sequences revealed that all jawed vertebrate alpha-globin clusters are flanked by MPG-C16orf35 and LUC7L, whereas all bird and mammal beta-globin clusters are embedded in olfactory genes. Thus, the mammalian alpha- and beta-globin clusters are orthologous to the bird alpha- and beta-globin clusters respectively.
conclusionWe propose that alpha- and beta-globin clusters evolved from an ancient MPG-C16orf35-alpha-beta-GBY-LUC7L arrangement 410 million years ago. A copy of the original beta (represented by omega in marsupials and monotremes) was inserted into an array of olfactory genes before the amniote radiation (>315 million years ago), then duplicated and diverged to form orthologous clusters of beta-globin genes with different expression profiles in different lineages.
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