ArticleImmunology2009
Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signals.
Article in Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- A novel strategy to screen Bacillus Calmette-Guérin protein antigen recognized by γδ TCR.PloS one · 2011Trial
- Vγ9Vδ2 T cells in tuberculosis: protective immunity and translational perspectives.Frontiers in immunology · 2026Review
- Effects of Maternal Supplementation with Organic Trace Minerals including Zinc, Manganese, Copper, and Cobalt during the Late and Post-Partum Periods on the Health and Immune Status of Japanese Black Calves.Animals : an open access journal from MDPI · 2023Article
- Clinical manifestations and immune response to tuberculosis.World journal of microbiology & biotechnology · 2023Review
- Bovine Immunity and Vitamin DMicroorganisms · 2022Review
- Whole-Blood Transcriptome Analysis of Feedlot Cattle With and Without Bovine Respiratory Disease.Frontiers in genetics · 2021Article
- Decreased Frequencies of Gamma/Delta T Cells Expressing Th1/Th17 Cytokine, Cytotoxic, and Immune Markers in Latent Tuberculosis-Diabetes/Pre-Diabetes Comorbidity.Frontiers in cellular and infection microbiology · 2021Article
- Bovine γδ T cells are a major regulatory T cell subset.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- γδ T Cell-Mediated Immune Responses in Disease and Therapy.Frontiers in immunology · 2014Review
- Identification of a new tuberculosis antigen recognized by γδ T cell receptor.Clinical and vaccine immunology : CVI · 2013Article
- Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection.Comparative immunology, microbiology and infectious diseases · 2012Article
- γδ T cells response to Mycobacterium tuberculosis in pulmonary tuberculosis patients using preponderant complementary determinant region 3 sequence.The Indian journal of medical research · 2011Article
- γδ T-APCs: a novel tool for immunotherapy?Cellular and molecular life sciences : CMLS · 2011Review
- Mesenteric lymph node cells from neonates present a prominent IL-12 response to CpG oligodeoxynucleotide via an IL-15 feedback loop of amplification.Veterinary research · 2011Article
- Comparative gamma delta T cell immunology: a focus on mycobacterial disease in cattle.Veterinary medicine international · 2011Article
- The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes.BMC genomics · 2010Article
- Gamma-delta T cell subsets are differentially associated with granuloma development and organization in a bovine model of mycobacterial disease.International journal of experimental pathology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Evidence suggests that gammadelta T cells form part of the innate immune response to Mycobacterium bovis infection. Dendritic cells (DCs) are capable of secreting high levels of interleukin-12 (IL-12) following infection with mycobacteria and can induce interferon-gamma (IFN-gamma) secretion by natural killer and gammadelta T cells We investigated the innate interactions occurring between WC1(+)gammadelta T cells and M. bovis-infected DCs. Following coculture with M. bovis-infected DCs, secretion of IFN-gamma and expression of CD25 and major histocompatibility complex class II on WC1(+)gammadelta T cells were significantly enhanced. Reciprocal enhancement of IL-12 secretion by the DCs was also observed and this interaction was found to be contact dependent. We hypothesize that there is an early, transient signal between the WC1(+)gammadelta T cells and the DCs, which promotes the synthesis of biologically active IL-12, and which is dependent upon cell-cell contact. Reciprocal signals including IL-12 are then delivered to WC1(+)gammadelta cells, which leads to the enhanced secretion of IFN-gamma, and the up-regulation of activation markers and antigen presentation molecules by the WC1(+)gammadelta T cells. These interactions are likely to form a critical part of the T helper type 1-conditioning response of DCs to M. bovis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.