ArticleThe European journal of neuroscience2008
Effects of H-reflex up-conditioning on GABAergic terminals on rat soleus motoneurons.
Article in The European journal of neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Relationship Between Spinal Reflexes and Spastic Movement Disorders.Physical medicine and rehabilitation clinics of North America · 2026Review
- Operant down-conditioning of the soleus H-reflex in people after stroke.Frontiers in rehabilitation sciences · 2022Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Effects of Repeated 20-Hz Electrical Stimulation on Functional Recovery Following Peripheral Nerve Injury.Neurorehabilitation and neural repair · 2019Article
- Operant conditioning of the motor-evoked potential and locomotion in people with and without chronic incomplete spinal cord injury.Journal of neurophysiology · 2019Article
- Operant conditioning of the tibialis anterior motor evoked potential in people with and without chronic incomplete spinal cord injury.Journal of neurophysiology · 2018Article
- The inferior olive is essential for long-term maintenance of a simple motor skill.Journal of neurophysiology · 2016Article
- Operant conditioning of spinal reflexes: from basic science to clinical therapy.Frontiers in integrative neuroscience · 2014Review
- Cortical stimulation causes long-term changes in H-reflexes and spinal motoneuron GABA receptors.Journal of neurophysiology · 2012Article
- H-reflex up-conditioning encourages recovery of EMG activity and H-reflexes after sciatic nerve transection and repair in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Activity-dependent plasticity of spinal locomotion: implications for sensory processing.Exercise and sport sciences reviews · 2009Article
- H-reflex down-conditioning greatly increases the number of identifiable GABAergic interneurons in rat ventral horn.Neuroscience letters · 2009Article
- The cerebellum in maintenance of a motor skill: a hierarchy of brain and spinal cord plasticity underlies H-reflex conditioning.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
To explore the role of spinal cord plasticity in motor learning, we evaluated the effects of H-reflex operant conditioning on GABAergic input to rat spinal motoneurons. Previous work indicated that down-conditioning of soleus H-reflex increases GABAergic input to soleus motoneurons. This study explored the effect of H-reflex up-conditioning on GABAergic input. Of nine rats exposed to H-reflex up-conditioning, up-conditioning was successful (H-reflex increase >or= 20%) in seven and failed (change < 20%) in two. These rats and eight naive control (i.e. unconditioned) rats were injected with cholera toxin subunit B-conjugated Alexa fluor 488 into the soleus muscle to retrogradely label soleus motoneurons. Sections containing soleus motoneurons were processed for GAD(67) [one of the two principal forms of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD)] with an ABC-peroxidase system. Two blinded independent raters counted and measured GABAergic terminals on these motoneurons. Unlike successful down-conditioning, which greatly increased the number of identifiable GABAergic terminals on the motoneurons, up-conditioning did not significantly change GABAergic terminal number. Successful up-conditioning did produce slight but statistically significant increases in GABAergic terminal diameter and soma coverage. These results are consistent with other data indicating that up- and down-conditioning are not mirror images of each other, but rather have different mechanisms. Although the marked changes in GABAergic terminals with down-conditioning probably contribute to H-reflex decrease, the modest changes in GABAergic terminals associated with up-conditioning may be compensatory or reactive plasticity, rather than the plasticity responsible for H-reflex increase. As a variety of spinal and supraspinal GABAergic neurons innervate motoneurons, the changes found with up-conditioning may be in terminals other than those affected in successful down-conditioning.
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