ArticleDevelopment, growth & differentiation2008
Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo.
Article in Development, growth & differentiation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Modeling Post-Implantation Mammalian Embryogenesis Using AdvancedInternational journal of molecular sciences · 2026Review
- A bioengineering approach to guide non-integrated stem cell-derived embryo model towards yolk sac development and hematopoiesis.Frontiers in cell and developmental biology · 2026Article
- Basement membrane perforations guide anterior-posterior axis formation.Nature communications · 2025Article
- Spatial transcriptomic characterization of a Carnegie stage 7 human embryo.Nature cell biology · 2025Article
- The role of BMP4 signaling in trophoblast emergence from pluripotency.Cellular and molecular life sciences : CMLS · 2022Review
- Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs.Nature communications · 2021Article
- Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro.Developmental cell · 2021Article
- A differentiation program induced by bone morphogenetic proteins 4 and 7 in endodermal epithelial cells provides the molecular basis for efficient nutrient transport by the chicken yolk sac.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Mouse embryo geometry drives formation of robust signaling gradients through receptor localization.Nature communications · 2019Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.Cell death & disease · 2018Article
- A molecular mechanism of symmetry breaking in the early chick embryo.Scientific reports · 2017Article
- Genetic redundancy of GATA factors in the extraembryonic trophoblast lineage ensures the progression of preimplantation and postimplantation mammalian development.Development (Cambridge, England) · 2017Article
- Human embryos cultured in vitro to 14 days.Open biology · 2017Review
- Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation.Scientific reports · 2016Article
- Methods for Precisely Localized Transfer of Cells or DNA into Early Postimplantation Mouse Embryos.Journal of visualized experiments : JoVE · 2015Article
- Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo.Developmental biology · 2012Article
- Dynamics of anterior-posterior axis formation in the developing mouse embryo.Nature communications · 2012Article
- BMP4 signaling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity.Developmental biology · 2012Article
- Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo.Nature reviews. Genetics · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The extraembryonic ectoderm (ExE) of the mouse conceptus is known to play a role in embryo patterning by signaling to the underlying epiblast and surrounding visceral endoderm. Bmp4 is one of the key ExE signaling molecules and has been recently implicated to participate in regulating development and migration of the anterior visceral endoderm (AVE). However, it remains unclear when exactly BMP4 signaling starts to regulate AVE positioning. To examine this, we have chosen to affect BMP4 function at two different time points, at embryonic day 5.25 (E5.25), thus before AVE migration, and E5.75, just after AVE migration. To this end, an RNAi technique was used, which consisted of the injection of Bmp4 dsRNA into the proamniotic cavity of the egg cylinder followed by its targeted electroporation into the ExE. This resulted in specific knockdown of Bmp4. It was found that Bmp4 RNAi at E5.25, but not at E5.75, led to an abnormal pattern of expression of the AVE marker Cerberus-like. Thus, BMP4 signaling appears to affect the expression of Cer1 at a specific time window. This RNAi approach provides a convenient means to study spatial and temporal function of genes shortly after embryo implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.