ArticleSurgery2008
Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resection.
Article in Surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway.Experimental & molecular medicine · 2026Article
- Bile acid signaling, metabolism, and aging.Liver research (Beijing, China) · 2026Review
- Colonic Adaptation Postileal Resection: Bile Acid Absorption in an Ileal Resection Mouse Model.Gastroenterology research and practice · 2025Article
- Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to ControlJournal of fungi (Basel, Switzerland) · 2022Article
- Lipid raft-mediated and upregulated coordination pathways assist transport of glycocholic acid-modified nanoparticle in a human breast cancer cell line of SK-BR-3.International journal of pharmaceutics · 2022Article
- Bile Acid Regulates the Colonization and Dissemination ofJournal of fungi (Basel, Switzerland) · 2021Article
- Intestinal Absorption of Bile Acids in Health and Disease.Comprehensive Physiology · 2019Review
- Effects of sanshoamides and capsaicinoids on plasma and liver lipid metabolism in hyperlipidemic rats.Food science and biotechnology · 2019Article
- Host-Gut Microbiota Crosstalk in Intestinal Adaptation.Cellular and molecular gastroenterology and hepatology · 2018Review
- Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection.Biology open · 2017Article
- Role of Gut Microbiota in the Aetiology of Obesity: Proposed Mechanisms and Review of the Literature.Journal of obesity · 2016Review
- Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery.Nature communications · 2015Article
- Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon.PloS one · 2013Article
- The impact of farnesoid X receptor activation on intestinal permeability in inflammatory bowel disease.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012Review
- Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice.The Journal of surgical research · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBile acid (BA) reclamation following ileo-cecal resection (ICR) may prevent colonic mucosa from chronic injury. In this study, we hypothesized that in a murine model of ICR the remnant colon would upregulate the cellular machinery necessary for BA reclamation and would do so in an FXR- and bacteria-dependent manner.
methodsConventional (WT), conventional FXR knockout (FXR null) and germ-free (GF) mice were randomized to undergo either ICR or sham operation. The ascending colon was harvested for histology and immunohistochemistry and changes in bile acid homeostatic gene expression determined by real-time polymerase chain reaction (RT-PCR) 7 days following surgery.
resultsFollowing ICR WT mice showed significant increases in the expression of genes regulating bile acid transport including IBABP, Asbt, Ost beta and FGF 15. Increased expression of IBABP and Asbt was confirmed by immunohistochemistry. Induction of bile acid transport genes was absent or attenuated in FXR null and GF mice.
conclusionBacterial dependent up regulation of IBABP is FXR mediated in the colon following ICR. Mice lacking microbiota (GF) or FXR are unable to increase the expression of IBABP or FGF 15.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.