ArticleMicrobial pathogenesis2008
The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells.
Article in Microbial pathogenesis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Review
- RACK1 promotesiScience · 2023Article
- The type 3 secretion system requires actin polymerization to open translocon pores.PLoS pathogens · 2021Article
- TheMicroorganisms · 2021Review
- Article
- Activation of Shigella flexneri type 3 secretion requires a host-induced conformational change to the translocon pore.PLoS pathogens · 2019Article
- The type III secretion system needle, tip, and translocon.Protein science : a publication of the Protein Society · 2019Review
- Article
- Immunogenic evaluation of chimeric recombinant proteinMolecular biology research communications · 2017Article
- BipC, a PredictedFrontiers in cellular and infection microbiology · 2017Article
- How Do the Virulence Factors ofFrontiers in cellular and infection microbiology · 2017Review
- Detergent Isolation Stabilizes and Activates the Shigella Type III Secretion System Translocator Protein IpaC.Journal of pharmaceutical sciences · 2016Article
- Intermediate filaments enable pathogen docking to trigger type 3 effector translocation.Nature microbiology · 2016Article
- Article
- Article
- Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins.International journal of molecular sciences · 2014Review
- Structure and biophysics of type III secretion in bacteria.Biochemistry · 2013Review
- Hierarchies of host factor dynamics at the entry site of Shigella flexneri during host cell invasion.Infection and immunity · 2012Article
- Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction.Infection and immunity · 2009Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Invasion plasmid antigen C (IpaC) is secreted by the Shigella flexneri type III secretion system (TTSS) as an essential trigger of epithelial cell invasion. At the molecular level, IpaC possesses a distinct functional organization. The IpaC C-terminal region between amino acids 319 and 345 is predicted to form a coiled-coil structure. Such alpha-helical motifs appear to be a recurring structural theme among TTSS components. Together with IpaB, this IpaC region is also required for the formation of translocon pores in target cell membranes. In contrast, mutations within the C-terminal tail of IpaC (defined by residues 345-363) have no effect on contact hemolysis (a putative measure of translocon pore formation), but they can contribute significantly to IpaC's ability to trigger S. flexneri entry into cultured cells. Here we describe the molecular dissection of the IpaC C-terminus and how changes in this region affect selected virulence-related activities. IpaC invasion function requires its immediate C-terminus and this general region may be involved in its ability to trigger actin nucleation. In contrast, IpaC could not be shown to interact directly with Cdc42, a host GTPase closely tied to Shigella invasion.
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