ArticleBrain research2008
Mechanically-induced cortical spreading depression associated regional cerebral blood flow changes are blocked by Na+ ion channel blockade.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Systematic review of the pharmacological agents that have been tested against spreading depolarizations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Olfactory Bulb Pinprick Induction of Cortical Spreading Depolarizations.bioRxiv : the preprint server for biology · 2025Article
- Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics.Frontiers in molecular neuroscience · 2024Review
- KCl-induced repetitive cortical spreading depression inhibiting trigeminal neuronal firing is mediated by 5-HTCephalalgia : an international journal of headache · 2022Article
- Action Potentials Are Critical for the Propagation of Focally Elicited Spreading Depolarizations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Spreading depression as a preclinical model of migraine.The journal of headache and pain · 2019Review
- Current Status of Antiepileptic Drugs as Preventive Migraine Therapy.Current treatment options in neurology · 2019Review
- Pathophysiology of Migraine: A Disorder of Sensory Processing.Physiological reviews · 2017Review
- Transcranial magnetic stimulation and potential cortical and trigeminothalamic mechanisms in migraine.Brain : a journal of neurology · 2016Article
- Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.Physiological reviews · 2015Review
- Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations.Nature reviews. Neuroscience · 2014Review
- Cortical spreading depression as a target for anti-migraine agents.The journal of headache and pain · 2013Review
- Critical role of calcitonin gene-related peptide receptors in cortical spreading depression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Cortical spreading depression-new insights and persistent questions.Cephalalgia : an international journal of headache · 2009Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine with aura occurs in up to 20-30% of all migraineurs. The regional cerebral blood flow (rCBF) changes that occur during cortical spreading depression (CSD) are considered to be an experimental correlate of aura. CSD is synchronous with a failure in brain ion homeostasis and efflux of excitatory amino acids from nerve cells. Therefore studying the mechanisms that underlie CSD, such as ion channel manipulation, and observing rCBF changes may help our understanding of migraine aura. In this study we used mechanical stimulation to induce oligemia and hyperemia, in surgically prepared cats and rats, using laser Doppler probes to measure the cerebral blood flow and single cell cortical recording to measure the spike/neuronal burst, both generated as a consequence of CSD. We looked at the response of ion channel blockers directed at sodium, voltage-dependent calcium and ATP-activated potassium ion channels. The sodium ion channel blocker was able to inhibit rCBF changes in both the cat and rats. Voltage-dependent calcium channel blockers had little effect on the initiation or propagation of the spread, as did the ATP-activated potassium channel blocker. The data are consistent with what is known of human aura in that sodium ion channels are those predominantly involved in mechanical stimulation-induced rCBF changes and thus may represent therapeutic targets for the aura response in migraine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.