ArticleBrain research2008
Spinal activation of the cAMP-PKA pathway induces respiratory motor recovery following high cervical spinal cord injury.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Targeted metabolome and transcriptome analyses reveal changes in gibberellin and related cell wall-acting enzyme-encoding genes during stipe elongation inFrontiers in microbiology · 2023Article
- Targeting drug or gene delivery to the phrenic motoneuron pool.Journal of neurophysiology · 2023Review
- Spinal activation of protein kinase C elicits phrenic motor facilitation.Respiratory physiology & neurobiology · 2018Article
- The crossed phrenic phenomenon.Neural regeneration research · 2017Review
- Transporter Protein-Coupled DPCPX Nanoconjugates Induce Diaphragmatic Recovery after SCI by Blocking Adenosine A1 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Ipsilateral inspiratory intercostal muscle activity after C2 spinal cord hemisection in rats.The journal of spinal cord medicine · 2015Article
- The pattern and extent of retrograde transsynaptic transport of WGA-Alexa 488 in the phrenic motor system is dependent upon the site of application.Journal of neuroscience methods · 2014Article
- Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation.Neuroscience · 2013Article
- Theophylline regulates inflammatory and neurotrophic factor signals in functional recovery after C2-hemisection in adult rats.Experimental neurology · 2012Article
- Treatments to restore respiratory function after spinal cord injury and their implications for regeneration, plasticity and adaptation.Experimental neurology · 2012Review
- Role of plasminogen activator in spinal cord remodeling after spinal cord injury.Respiratory physiology & neurobiology · 2009Review
- Respiratory recovery following high cervical hemisection.Respiratory physiology & neurobiology · 2009Review
- The crossed phrenic phenomenon and recovery of function following spinal cord injury.Respiratory physiology & neurobiology · 2009Review
- Dose and chemical modification considerations for continuous cyclic AMP analog delivery to the injured CNS.Journal of neurotrauma · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The present study investigated the involvement of the adenosine 3'5'-cyclic monophosphate-dependent protein kinase A (cAMP-PKA) pathway in the activation of the crossed-phrenic pathways after left C2 spinal cord hemisection. Experiments were conducted on left C2 spinal cord hemisected, anesthetized, vagotomized, pancuronium paralyzed, and artificially ventilated male Sprague-Dawley rats. One week post-injury, the ipsilateral phrenic nerve exhibited no respiratory-related activity indicating a functionally complete hemisection. Intrathecal spinal cord administration of the cAMP analog, 8-Br-cAMP at the level of the phrenic nucleus resulted in an enhancement of contralateral phrenic nerve output and a restoration of respiratory-related activity in the phrenic nerve ipsilateral to the hemisection. Furthermore, pre-treatment with Rp-8-Br-cAMP, a PKA inhibitor, abolished the effects of 8-Br-cAMP. These results suggest that PKA activation is necessary for the cAMP-mediated respiratory recovery following high cervical spinal cord injury and that activation of intracellular signaling cascades may represent an important strategy for improving respiratory function after spinal cord injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.