ArticlePeptides2008
Mechanisms of action of CCK to activate central vagal afferent terminals.
Article in Peptides, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Cholecystokinin Induces CaThe European journal of neuroscience · 2026Article
- The vagus nerve promotes memory in rats via nutrient-induced septo-hippocampal acetylcholine signaling.Nature communications · 2026Article
- Article
- The Duodenum-Centered Neurohormonal Hypothesis of Type 2 Diabetes: A Mechanistic Review and Therapeutic Perspective.Current issues in molecular biology · 2025Review
- Minimally invasive, wide-field two-photon imaging of the brainstem at cellular resolution.Cell reports methods · 2025Article
- Gut Microbiome Regulation of Gut Hormone Secretion.Endocrinology · 2025Review
- Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating.Cell metabolism · 2024Article
- Role of the gut-brain axis in energy and glucose metabolism.Experimental & molecular medicine · 2022Review
- The Function of Gastrointestinal Hormones in Obesity-Implications for the Regulation of Energy Intake.Nutrients · 2021Review
- Review
- Contributing mechanisms underlying desensitization of cholecystokinin-induced activation of primary nodose ganglia neurons.American journal of physiology. Cell physiology · 2020Article
- The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release.Frontiers in physiology · 2019Article
- Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders.Frontiers in psychiatry · 2018Review
- Nutritional status-dependent endocannabinoid signalling regulates the integration of rat visceral information.The Journal of physiology · 2017Article
- From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation.International journal of molecular sciences · 2017Review
- Plasticity of vagal afferent signaling in the gut.Medicina (Kaunas, Lithuania) · 2017Review
- Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Incretin hormones and the satiation signal.International journal of obesity (2005) · 2013Review
- Gastric vagal afferent modulation by leptin is influenced by food intake status.The Journal of physiology · 2013Article
- Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Cholecystokinin [CCK] is a peptide released as a hormone by the proximal gut in response to the presence of peptones and fatty acid in the gut. Considerable evidence suggests that CCK inhibits feeding behavior and gastric function by acting as a paracrine modulator of vagal afferents in the periphery, especially in the duodenum. CCK is also widely distributed throughout the mammalian brain and appears to function as a neurotransmitter and neuromodulator. More recent studies have suggested that CCK may act directly within the CNS to activate central vagal afferent terminal inputs to the solitary nucleus. We have developed an in vitro calcium imaging method that reveals, for the first time, the direct effects of this peptide on vagal terminals in the solitary nucleus. In vitro imaging reveals that CCK provokes increases in intracellular calcium in vagal afferent terminals as a consequence of a complex interaction between protein kinase A [PKA] and phospholipase C [PLC] transduction mechanisms that open L-type calcium channels and causes endoplasmic reticular [ER] calcium release. The subsequent activation of PKC may be responsible for initiating calcium spiking which is dependent on a TTX-sensitive mechanism. Thus, imaging of the isolated but spatially intact hindbrain slice has allowed a more complete appreciation of the interdependent transduction mechanisms used by CCK to excite identified central vagal afferent fibers and varicosities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.