ArticleSleep2008
Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study.
Article in Sleep, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03949296 (A Randomized, Placebo-Controlled Study of Mindfulness Meditation in Treating Insomnia in Multiple Sclerosis), which is not on this map. Cited by 65 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Placebo-Controlled Study of Mindfulness Meditation in Treating Insomnia in Multiple Sclerosis
Who cites it
65 citing papers in PubMed, 4 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis.PloS one · 2025Pooled it
- [Frequent neurological diseases associated with the restless legs syndrome].Der Nervenarzt · 2018Pooled it
- A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015Pooled it
- A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015Pooled it
- Tetrahydrocannabinol/cannabidiol in the treatment of restless legs syndrome.Journal of neurology · 2026Trial
- Comorbidity and modifiable risk factors in multiple sclerosis.Therapeutic advances in neurological disorders · 2026Review
- Sleep disorders and associated factors in multiple sclerosis patients: a cross-sectional study in Iran.BMC neurology · 2025Article
- Sleep Disorders in a Sample of Patients with Pediatric-Onset Multiple Sclerosis: Focus on Restless Legs Syndrome.Journal of clinical medicine · 2025Article
- Restless leg syndrome in multiple sclerosis: a case-control study.Frontiers in neurology · 2023Article
- Sleep disorders in multiple sclerosis: a case-control study using the São Paulo Epidemiologic sleep study (Episono) database.Arquivos de neuro-psiquiatria · 2022Article
- Prevalence of restless legs syndrome in people with diabetes mellitus: A pooling analysis of observational studies.EClinicalMedicine · 2022Article
- Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression.Arquivos de neuro-psiquiatria · 2022Article
- Leg movement activity during sleep in multiple sclerosis with and without restless legs syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Observational
- Movement Disorders in Multiple Sclerosis: An Update.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Review
- Restless Legs Syndrome in Multiple Sclerosis.Noro psikiyatri arsivi · 2021Article
- Therapeutic Approaches to Insomnia and Fatigue in Patients with Multiple Sclerosis.Nature and science of sleep · 2021Review
- Co-occurrence of Fatigue and Depression in People With Multiple Sclerosis: A Mini-Review.Frontiers in neurology · 2021Review
- Sleep Disturbances Associated with Neurological Autoimmunity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Excessive daytime sleepiness and fatigue in neurological disorders.Sleep & breathing = Schlaf & Atmung · 2020Review
- Better Objective Sleep Was Associated with Better Subjective Sleep and Physical Activity; Results from an Exploratory Study under Naturalistic Conditions among Persons with Multiple Sclerosis.International journal of environmental research and public health · 2020Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
53 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors.
designProspective, multicenter, case-control epidemiologic survey. SETTINGS: Twenty sleep centers certified by the Italian Association of Sleep Medicine. PATIENTS: Eight hundred and sixty-one patients affected by MS and 649 control subjects.
interventionsN/A. MEASURES AND
resultsData regarding demographic and clinical factors, presence and severity of RLS, the results of hematologic tests, and visual analysis of cerebrospinal magnetic resonance imaging studies were collected. The prevalence of RLS was 19% in MS and 4.2% in control subjects, with a risk to be affected by RLS of 5.4 (95%confidence interval: 3.56-8.26) times greater for patients with MS than for control subjects. In patients with MS, the following risk factors for RLS were significant: older age; longer MS duration; the primary progressive MS form; higher global, pyramidal, and sensory disability; and the presence of leg jerks before sleep onset. Patients with MS and RLS more often had sleep complaints and a higher intake of hypnotic medications than patients with MS without RLS. RLS associated with MS was more severe than that of control subjects.
conclusionsRLS is significantly associated with MS, especially in patients with severe pyramidal and sensory disability. These results strengthen the idea that the inflammatory damage correlated with MS may induce a secondary form of RLS. As it does in idiopathic cases, RLS has a significant impact on sleep quality in patients with MS; therefore, it should be always searched for, particularly in the presence of insomnia unresponsive to treatment with common hypnotic drugs.
Indexed as
Identifiers
18655317PMC2491510W2127766042What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.