ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2009
Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaques.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
- Dorsal raphe neurons signal integrated value during multi-attribute decision-making.bioRxiv : the preprint server for biology · 2023Article
- Problem Solving in Animals: Proposal for an Ontogenetic Perspective.Animals : an open access journal from MDPI · 2021Review
- Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning.Psychology & neuroscience · 2020Article
- The neural basis of reversal learning: An updated perspective.Neuroscience · 2017Review
- Differential serotonergic innervation of the amygdala in bonobos and chimpanzees.Social cognitive and affective neuroscience · 2016Article
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- Dissecting impulsivity and its relationships to drug addictions.Annals of the New York Academy of Sciences · 2014Review
- The neural and genetic basis of executive function: attention, cognitive flexibility, and response inhibition.Pharmacology, biochemistry, and behavior · 2014Review
- The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague-Dawley rats of different ages.Pharmacology, biochemistry, and behavior · 2014Article
- Reward, interrupted: Inhibitory control and its relevance to addictions.Neuropharmacology · 2014Review
- Effects of repeated adolescent stress and serotonin transporter gene partial knockout in mice on behaviors and brain structures relevant to major depression.Frontiers in behavioral neuroscience · 2013Article
- On the evolution of the serotonin transporter linked polymorphic region (5-HTTLPR) in primates.Frontiers in human neuroscience · 2013Article
- Reversal learning as a measure of impulsive and compulsive behavior in addictions.Psychopharmacology · 2012Review
- Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A neurochemical yin and yang: does serotonin activate and norepinephrine deactivate the prefrontal cortex?Psychopharmacology · 2011Review
- A natural genetic polymorphism affects retroactive interference in Drosophila melanogaster.Proceedings. Biological sciences · 2011Article
- Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
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4 authors at 2 institutions in 1 country.
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Abstract
The serotonin system is an important neurophysiological mediator of many behavioral phenotypes. Genetic variation within this system is thought to contribute not only to the natural range of behavioral differences, but also to neuropsychiatric pathologies. Cognitive flexibility, the ability to change patterns of response as reward context shifts, is an important trait that underlies many complex social interactions. Environmental manipulations of the serotonin system have been shown to alter performance on tests measuring cognitive flexibility. Variation at the serotonin transporter promoter region (5HTTLPR) has recently been shown to associate with the performance of rhesus monkeys on an object discrimination reversal learning task [Izquierdo et al., 2007]. Here, we demonstrate that functional genetic variation at the serotonin transporter 3' untranslated region, independent of 5HTTLPR, also associates with performance in an object discrimination reversal learning task in rhesus macaques. The polymorphisms comprising the T:G:T haplotype (T1970, G1991, and T2327) were associated with fewer errors on a reversal learning test and greater levels of cognitive flexibility. We have previously demonstrated that the T:G:T haplotype renders lower levels of gene expression in vitro, paralleling the functionality of human 3' UTR haplotypes, as well as the short allele of 5HTTLPR found in both macaques and humans. The 3' UTR haplotypes are independent and in linkage equilibrium with the 5HTTLPR locus. Together, these data lead to the intriguing possibility that differences observed in human cognitive flexibility, whether naturally or in pathological states, may be associated with genetic variation in the serotonin transporter 3' untranslated region also.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.