ArticleJournal of molecular evolution2008
Variation in constraint versus positive selection as an explanation for evolutionary rate variation among anthocyanin genes.
Article in Journal of molecular evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 80 citations in OpenAlex.
- Transcription Factors Evolve Faster Than Their Structural Gene Targets in the Flavonoid Pigment Pathway.Molecular biology and evolution · 2022Article
- Article
- Gene expression predictions and networks in natural populations supports the omnigenic theory.BMC genomics · 2020Article
- Evolutionary rate variation among genes involved in galactomannan biosynthesis inEcology and evolution · 2020Article
- Influence of pathway topology and functional class on the molecular evolution of human metabolic genes.PloS one · 2018Article
- Signatures of natural selection in abiotic stress-responsive genes ofRoyal Society open science · 2018Article
- The factors affecting the evolution of the anthocyanin biosynthesis pathway genes in monocot and dicot plant species.BMC plant biology · 2017Article
- New views on the selection acting on genetic polymorphism in central metabolic genes.Annals of the New York Academy of Sciences · 2017Review
- Connectivity in gene coexpression networks negatively correlates with rates of molecular evolution in flowering plants.PloS one · 2017Article
- Imbalanced positive selection maintains the functional divergence of duplicated DIHYDROKAEMPFEROL 4-REDUCTASE genes.Scientific reports · 2016Article
- Domestication and the storage starch biosynthesis pathway: signatures of selection from a whole sorghum genome sequencing strategy.Plant biotechnology journal · 2016Article
- Article
- Diversifying selection of the anthocyanin biosynthetic downstream gene UFGT accelerates floral diversity of island Scutellaria species.BMC evolutionary biology · 2016Article
- Molecular evolution of anthocyanin pigmentation genes following losses of flower color.BMC evolutionary biology · 2016Article
- Evolutionary Rate Heterogeneity of Primary and Secondary Metabolic Pathway Genes in Arabidopsis thaliana.Genome biology and evolution · 2015Article
- Evolutionary study of the isoflavonoid pathway based on multiple copies analysis in soybean.BMC genetics · 2014Article
- Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom.PloS one · 2014Article
- Evolutionary rate patterns of genes involved in the Drosophila Toll and Imd signaling pathway.BMC evolutionary biology · 2013Article
- Sequence diversity in coding regions of candidate genes in the glycoalkaloid biosynthetic pathway of wild potato species.G3 (Bethesda, Md.) · 2013Article
- A system-level, molecular evolutionary analysis of mammalian phototransduction.BMC evolutionary biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been argued that downstream enzymes in metabolic pathways are expected to be subject to reduced selective constraint, while upstream enzymes, particularly those at pathway branch points, are expected to exhibit more frequent adaptive substitution than downstream enzymes. We examined whether these expectations are met for enzymes in the anthocyanin biosynthetic pathway in Ipomoea. Previous investigations have demonstrated that downstream enzymes in this pathway have substantially higher rates of nonsynonymous substitution than upstream enzymes. We demonstrate here that the difference in rates between the most upstream enzyme (CHS) and the two most downstream enzymes (ANS and UFGT) is explained almost entirely by differences in levels of selective constraint. Adaptive substitutions were not detected in any of these genes. Our results are consistent with suggestions that constraint is greater on enzymes with greater connectivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.