ArticleParasitology research2008
Schistosoma japonicum infection modulates the development of allergen-induced airway inflammation in mice.
Article in Parasitology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Characterization of a chitinase from Trichinella spiralis and its immunomodulatory effects on allergic airway inflammation in mice.Parasites & vectors · 2025Article
- Emu-miR-10a-5p inFrontiers in immunology · 2025Article
- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- Excretory/Secretory Products from Schistosoma japonicum Eggs Alleviate Ovalbumin-Induced Allergic Airway Inflammation.PLoS neglected tropical diseases · 2023Article
- Schistosome Infection and Schistosome-Derived Products as Modulators for the Prevention and Alleviation of Immunological Disorders.Frontiers in immunology · 2021Review
- Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection.Frontiers in immunology · 2021Review
- Behind Enemy Lines: Immunomodulatory Armamentarium of the Schistosome Parasite.Frontiers in immunology · 2020Review
- What Can Parasites Tell Us About the Pathogenesis and Treatment of Asthma and Allergic Diseases.Frontiers in immunology · 2020Review
- Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice.Journal of cellular and molecular medicine · 2019Article
- Preventive and therapeutic effects of Trichinella spiralis adult extracts on allergic inflammation in an experimental asthma mouse model.Parasites & vectors · 2019Article
- Role of mast cells in the generation of a T-helper type 2 dominated anti-helminthic immune response.Bioscience reports · 2019Article
- Effect of regulatory T cells on the efficacy of the fatty acid-binding protein vaccine against Schistosoma japonicum.Parasitology research · 2019Article
- Isolated Schistosoma mansoni eggs prevent allergic airway inflammation.Parasite immunology · 2018Article
- Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma.Frontiers in physiology · 2018Article
- Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice.PloS one · 2017Article
- Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.JCI insight · 2016Article
- Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis.Journal of immunology research · 2016Review
- Schistosome-Derived Molecules as Modulating Actors of the Immune System and Promising Candidates to Treat Autoimmune and Inflammatory Diseases.Journal of immunology research · 2016Review
- The secretions products from invading cercariae of S. japonicum (0-3hRP) restrain mouse dendritic cells to mature.Parasitology research · 2012Article
- The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial.Journal of parasitology research · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma, a chronic inflammatory disorder of the airways, is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. It has been shown that helminth infections including Schistosoma mansoni may modulate atopic diseases including asthma. In the present study, BALB/c mice were infected with bisexual and unisexual (male) S. japonicum, respectively, prior to ovalbumin (OVA) sensitization and challenge. Compared to mice with OVA sensitization/challenge alone, S. japonicum infection led to a significant decrease of eosinophil accumulation in bronchoalveolar lavage fluid (BALF) collected 48 h postchallenge, as well as to a marked reduction in inflammatory cell infiltration around the airways and pulmonary blood vessels. Compared to OVA-immunized uninfected mice, the level of OVA-specific serum IgE as well as interleukin (IL)-4 and IL-5 in BALF were reduced, but IL-10 was strongly elevated in mice with preexisting S. japonicum infection prior to OVA immunization. These results suggest that both bisexual and male S. japonicum infections may modulate the development of allergic asthma.
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