ArticlePLoS genetics2008
The status of dosage compensation in the multiple X chromosomes of the platypus.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 106 citations in OpenAlex.
- Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024Review
- Article
- The Molecular and Nuclear Dynamics of X-Chromosome Inactivation.Cold Spring Harbor perspectives in biology · 2022Review
- A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Evolution, Expression and Meiotic Behavior of Genes Involved in Chromosome Segregation of Monotremes.Genes · 2021Article
- Review
- Article
- Evolution of Sex Chromosome Dosage Compensation in Animals: A Beautiful Theory, Undermined by Facts and Bedeviled by Details.Genome biology and evolution · 2017Review
- Evolution of Dosage Compensation in Anolis carolinensis, a Reptile with XX/XY Chromosomal Sex Determination.Genome biology and evolution · 2017Article
- Evolution of vertebrate sex chromosomes and dosage compensation.Nature reviews. Genetics · 2016Review
- Weird mammals provide insights into the evolution of mammalian sex chromosomes and dosage compensation.Journal of genetics · 2015Review
- Mechanisms of x chromosome dosage compensation.Journal of genomics · 2015Review
- Estimating tempo and mode of Y chromosome turnover: explaining Y chromosome loss with the fragile Y hypothesis.Genetics · 2014Article
- The evolutionary pathway of x chromosome inactivation in mammals.Acta naturae · 2013Article
- Determination of dosage compensation of the mammalian X chromosome by RNA-seq is dependent on analytical approach.BMC genomics · 2013Article
- Independent evolution of transcriptional inactivation on sex chromosomes in birds and mammals.PLoS genetics · 2013Article
- Trade-off between selection for dosage compensation and masculinization on the avian Z chromosome.Genetics · 2012Article
- Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Battle of the sexes: conflict over dosage-sensitive genes and the origin of X chromosome inactivation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation.Chromosoma · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dosage compensation has been thought to be a ubiquitous property of sex chromosomes that are represented differently in males and females. The expression of most X-borne genes is equalized between XX females and XY males in therian mammals (marsupials and "placentals") by inactivating one X chromosome in female somatic cells. However, compensation seems not to be strictly required to equalize the expression of most Z-borne genes between ZZ male and ZW female birds. Whether dosage compensation operates in the third mammal lineage, the egg-laying monotremes, is of considerable interest, since the platypus has a complex sex chromosome system in which five X and five Y chromosomes share considerable genetic homology with the chicken ZW sex chromosome pair, but not with therian XY chromosomes. The assignment of genes to four platypus X chromosomes allowed us to examine X dosage compensation in this unique species. Quantitative PCR showed a range of compensation, but SNP analysis of several X-borne genes showed that both alleles are transcribed in a heterozygous female. Transcription of 14 BACs representing 19 X-borne genes was examined by RNA-FISH in female and male fibroblasts. An autosomal control gene was expressed from both alleles in nearly all nuclei, and four pseudoautosomal BACs were usually expressed from both alleles in male as well as female nuclei, showing that their Y loci are active. However, nine X-specific BACs were usually transcribed from only one allele. This suggests that while some genes on the platypus X are not dosage compensated, other genes do show some form of compensation via stochastic transcriptional inhibition, perhaps representing an ancestral system that evolved to be more tightly controlled in placental mammals such as human and mouse.
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