ArticleJapanese journal of infectious diseases2008
vacA genotypes of Helicobacter pylori in relation to cagA status and clinical outcomes in Iranian populations.
Article in Japanese journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis.BMC gastroenterology · 2020Pooled it
- Helicobacter Pylori infection among Iranian patients with normal upper gastrointestinal endoscopy.Caspian journal of internal medicine · 2022Article
- Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review.Clinical and experimental gastroenterology · 2020Review
- Clarithromycin-Susceptible But VirulentInfection and drug resistance · 2019Article
- Genotyping and antibiotic resistance properties ofInfection and drug resistance · 2018Article
- Prevalence ofBioMed research international · 2017Article
- vacA Genotype Status of Helicobacter pylori Isolated from Foods with Animal Origin.BioMed research international · 2016Article
- The study of the oipA and dupA genes in Helicobacter pylori strains and their relationship with different gastroduodenal diseases.Gastroenterology and hepatology from bed to bench · 2015Article
- Association Between Helicobacter pylori cagA, babA2 Virulence Factors and Gastric Mucosal Interleukin-33 mRNA Expression and Clinical Outcomes in Dyspeptic Patients.International journal of molecular and cellular medicine · 2015Article
- EPIYA motiefs of cagA and upper gastrointestinal diseases.Gastroenterology and hepatology from bed to bench · 2015Article
- Helicobacter pylori vacA as marker for gastric cancer and gastroduodenal diseases: one but not the only factor.Journal of clinical microbiology · 2014Article
- Study of Helicobacter pylori genotype status in cows, sheep, goats and human beings.BMC gastroenterology · 2014Article
- Helicobacter pylori in vegetables and salads: genotyping and antimicrobial resistance properties.BioMed research international · 2014Article
- Prevalence of Helicobacter pylori vacA different genotypes in Isfahan, Iran.Advanced biomedical research · 2014Article
- CagA and VacA genotypes in peptic ulcer disease and non-ulcer dyspepsia: a case-control study.Medical journal of the Islamic Republic of Iran · 2014Article
- Association between Helicobacter pylori, cagA, and vacA Status and Clinical Presentation in Iranian Children.Iranian journal of pediatrics · 2013Article
- Genetic Analysis of cagA and vacA Genes in Helicobacter Pylori Isolates and Their Relationship with Gastroduodenal Diseases in the West of Iran.Iranian Red Crescent medical journal · 2013Article
- Low frequency of cagA-positive Helicobacter pylori strains isolated from Iranian patients with MALT lymphoma.Internal and emergency medicine · 2013Article
- Diversity of Helicobacter Pylori cagA and vacA Genes and Its Relationship with Clinical Outcomes in Azerbaijan, Iran.Advanced pharmaceutical bulletin · 2013Article
- Prevalence and distribution of Helicobacter pylori cagA and vacA genotypes in the Moroccan population with gastric disease.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Mosaicism in vacA alleles with two distinct families of vacA signal sequences (s1 and s2) and two distinct families of middle region alleles (m1 and m2) has been reported. Research suggests that the vacA s1 genotype is closely associated with duodenal ulcer disease and with high cytotoxin production. The aims of this study were to evaluate the role of vacA genotyping with respect to gastric inflammation and injury, and clinical presentation in Iranian populations. Genomic DNA of biopsy specimens from patients with gastritis, peptic ulcer disease (PUD), or gastric cancer (GC) were characterized based on ureC (glmM), cagA, and vacA genotyping by using polymerase chain reaction. Of 167 patients including 33 with PUDs, 129 with non-ulcer dyspepsia (NUD), and 5 with GC, 96 (57.5%) cases were infected by Helicobacter pylori. Among these patients, H. pylori were isolated from 19 (57.7%) PUD patients, 74 (68.7%) NUD patients, and 3 (60%) GC patients. The cagA was detected in 76% of H. pylori-positive cases. The vacA s1-m2 genotype was the most prevalent in 7/19 PUD (37%) and 30/74 NUD (40.5%) patients with H. pylori infection. The prevalence of vacA s2-m1 (8%) was high in Iranian isolates. A significant association was not found between H. pylori genotypes and clinical outcomes. The vacA genotypes and cagA status were not useful markers for gastroduodenal diseases in Tehran, Iran.
Indexed as
Identifiers
18653971PMC3719049W2108208483What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.