ArticleProceedings of the National Academy of Sciences of the United States of America2008
Systems analysis of the single photon response in invertebrate photoreceptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- Sparse identification of contrast gain control in the fruit fly photoreceptor and amacrine cell layer.Journal of mathematical neuroscience · 2020Article
- Point process analysis of noise in early invertebrate vision.PLoS computational biology · 2017Article
- A biomimetic fly photoreceptor model elucidates how stochastic adaptive quantal sampling provides a large dynamic range.The Journal of physiology · 2017Review
- Random Photon Absorption Model Elucidates How Early Gain Control in Fly Photoreceptors Arises from Quantal Sampling.Frontiers in computational neuroscience · 2016Article
- Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Fractional Ca(2+) currents through TRP and TRPL channels in Drosophila photoreceptors.Biophysical journal · 2013Article
- Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors.Journal of neurophysiology · 2013Article
- Stochastic, adaptive sampling of information by microvilli in fly photoreceptors.Current biology : CB · 2012Article
- Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Epistasis in a model of molecular signal transduction.PLoS computational biology · 2011Article
- Phototransduction motifs and variations.Cell · 2009Review
- Drosophila photoreceptors and signaling mechanisms.Frontiers in cellular neuroscience · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Photoreceptors of Drosophila compound eye employ a G protein-mediated signaling pathway that transduces single photons into transient electrical responses called "quantum bumps" (QB). Although most of the molecular components of this pathway are already known, the system-level understanding of the mechanism of QB generation has remained elusive. Here, we present a quantitative model explaining how QBs emerge from stochastic nonlinear dynamics of the signaling cascade. The model shows that the cascade acts as an "integrate and fire" device and explains how photoreceptors achieve reliable responses to light although keeping low background in the dark. The model predicts the nontrivial behavior of mutants that enhance or suppress signaling and explains the dependence on external calcium, which controls feedback regulation. The results provide insight into physiological questions such as single-photon response efficiency and the adaptation of response to high incident-light level. The system-level analysis enabled by modeling phototransduction provides a foundation for understanding G protein signaling pathways less amenable to quantitative approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.