ArticleMolecular biology and evolution2008
Recent origins of sperm genes in Drosophila.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 50 citations in OpenAlex.
- Functional analysis of genes enriched in male reproductive organs: validation via fertility assessment of 14 knockout mouse lines.Frontiers in cell and developmental biology · 2026Article
- Analysis of Transcript Expression and Core Promoter DNA Sequences of Brain, Adipose Tissues and Testis in Human and Fruit Fly.International journal of molecular sciences · 2025Article
- An Orphan Gene Enhances Male Reproductive Success in Plutella xylostella.Molecular biology and evolution · 2024Article
- Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans.PLoS biology · 2023Article
- Rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors.Nature ecology & evolution · 2021Article
- Identification of GOLPH3 Partners inCells · 2021Article
- A putative de novo evolved gene required for spermatid chromatin condensation in Drosophila melanogaster.PLoS genetics · 2021Article
- A Likelihood Approach for Uncovering Selective Sweep Signatures from Haplotype Data.Molecular biology and evolution · 2020Article
- The Role of Y Chromosome Genes in Male Fertility inGenetics · 2020Article
- Positive Selection in the Evolution of Mammalian CRISPs.Journal of molecular evolution · 2018Article
- Contrasting patterns of evolutionary constraint and novelty revealed by comparative sperm proteomic analysis in Lepidoptera.BMC genomics · 2017Article
- The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo.Molecular biology and evolution · 2017Article
- Relocation facilitates the acquisition of short cis-regulatory regions that drive the expression of retrogenes during spermatogenesis in Drosophila.Molecular biology and evolution · 2014Article
- Structure of androcam supports specialized interactions with myosin VI.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Drosophila sperm proteome evolution: Insights from comparative genomic approaches.Spermatogenesis · 2012Article
- Functional evidence that a recently evolved Drosophila sperm-specific gene boosts sperm competition.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Dynamic programming procedure for searching optimal models to estimate substitution rates based on the maximum-likelihood method.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm.BMC genomics · 2011Article
- Article
- Sperm proteomics reveals intensified selection on mouse sperm membrane and acrosome genes.Molecular biology and evolution · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Newly created genes often acquire testis-specific or enhanced expression but neither the mechanisms responsible for this specificity nor the functional consequences of these evolutionary processes are well understood. Genomic analyses of the Drosophila melanogaster sperm proteome has identified 2 recently evolved gene families on the melanogaster lineage and 4 genes created by retrotransposition during the evolution of the melanogaster group that encode novel sperm components. The expanded Mst35B (protamine) and tektin gene families are the result of tandem duplication events with all family members displaying testis-specific expression. The Mst35B family encodes rapidly evolving protamines that display a robust signature of positive selection within the DNA-binding high-mobility group box consistent with functional diversification in genome repackaging during sperm nuclear remodeling. The Mst35B paralogs also reside in a significant regional cluster of testis-overexpressed genes. Tektins, known components of the axoneme, are encoded by 3 nearly identical X-linked genes, a finding consistent with very recent gene family expansion. In addition to localized duplication events, the evolution of the sperm proteome has also been driven by recent retrotransposition events resulting in Cdlc2, CG13340, Vha36, and CG4706. Cdlc2, CG13340, and Vha36 all display high levels of overexpression in the testis, and Cdlc2 and CG13340 reside within testis-overexpressed gene clusters. Thus, gene creation is a dynamic force in the evolution of sperm composition and possibly function, which further suggests that acquisition of molecular functionality in sperm may be an influential pathway in the fixation of new genes.
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