ReviewArchives of disease in childhood. Fetal and neonatal edition2008
When to transfuse preterm babies.
Review in Archives of disease in childhood. Fetal and neonatal edition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- Short-term use of parenteral nutrition with a lipid emulsion containing a mixture of soybean oil, olive oil, medium-chain triglycerides, and fish oil: a randomized double-blind study in preterm infants.JPEN. Journal of parenteral and enteral nutrition · 2012Trial
- Acute physiological effects of packed red blood cell transfusion in preterm infants with different degrees of anaemia.Archives of disease in childhood. Fetal and neonatal edition · 2011Trial
- Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2011Trial
- Management of refined and personalized newborn blood specimen collection.Practical laboratory medicine · 2024Article
- Effect of Small Volume Blood Sampling on the Outcomes of Very Low Birth Weight Preterm Infants.Children (Basel, Switzerland) · 2022Article
- Evaluation and Treatment of Anemia in Premature Infants.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units.Blood transfusion = Trasfusione del sangue · 2014Article
- Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants.Pediatric research · 2014Article
- The effect of maximum storage on iron status, oxidative stress and antioxidant protection in paediatric packed cell units.Blood transfusion = Trasfusione del sangue · 2013Article
- Changes in regional tissue oxygenation saturation and desaturations after red blood cell transfusion in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2013Article
- Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion.Seminars in perinatology · 2012Review
- Blood cell counting in neonates: a comparison between a low volume micromethod and the standard laboratory method.Blood transfusion = Trasfusione del sangue · 2011Article
- Transfusion support in preterm neonates <1500 g and/or <32 weeks in a tertiary care center: A descriptive study.Asian journal of transfusion scienceArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The physiological anaemia experienced by preterm babies is exacerbated by common care practices such as early clamping of the umbilical cord at birth and gradual exsanguination by phlebotomy for laboratory monitoring. The need for subsequent transfusion with red blood cells can be reduced by delaying cord clamping for 30-60 s in infants who do not require immediate resuscitation. The need for transfusions can be further reduced by limiting phlebotomy losses, providing good nutrition, and using standard guidelines for transfusion based on haemoglobin or haematocrit. What those guidelines should be is not clear. Analysis of two recent large clinical trials comparing restrictive and liberal transfusion guidelines leads to several conclusions. Restrictive transfusion guidelines may reduce the number of transfusions given, but there is no reduction in donor exposures if a single-donor transfusion programme is used. There is some evidence that more liberal transfusion guidelines may help to prevent brain injury, but information on the impact of transfusion practice on long-term outcome is lacking. Until further guidance emerges, transfusion thresholds lower than those used in the two trials should not be used, as there is no evidence that lower thresholds are safe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.