ArticleDevelopment (Cambridge, England)2008
Fgf9 signaling regulates small intestinal elongation and mesenchymal development.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- Gastric hypoplasia in mice lacking fibroblast growth factor 9.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Hox gene activity directs physical forces to differentially shape chick small and large intestinal epithelia.Developmental cell · 2024Article
- Fgf9 promotes incisor dental epithelial stem cell survival and enamel formation.Stem cell research & therapy · 2024Article
- Article
- The duct of von Ebner's glands is a source ofFrontiers in cell and developmental biology · 2024Article
- A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche.BMC biology · 2023Article
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- Taste buds are not derived from neural crest in mouse, chicken, and zebrafish.Developmental biology · 2021Article
- Distinct Signaling Pathways DistinguishFrontiers in cell and developmental biology · 2021Article
- Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn's Disease.Developmental cell · 2020Article
- Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration.JCI insight · 2020Article
- Large intestine embryogenesis: Molecular pathways and related disorders (Review).International journal of molecular medicine · 2020Review
- Mesothelium and Malignant Mesothelioma.Journal of developmental biology · 2019Review
- Signals and forces shaping organogenesis of the small intestine.Current topics in developmental biology · 2019Review
- Mechanical Tension Drives Elongational Growth of the Embryonic Gut.Scientific reports · 2018Article
- Exogenous transforming growth factor-β1 enhances smooth muscle differentiation in embryonic mouse jejunal explants.Journal of tissue engineering and regenerative medicine · 2018Article
- Chick midgut morphogenesis.The International journal of developmental biology · 2018Review
- Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization.Structure (London, England : 1993) · 2017Article
- Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene.Genesis (New York, N.Y. : 2000) · 2017Article
- Morphogenesis and maturation of the embryonic and postnatal intestine.Seminars in cell & developmental biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Short bowel syndrome is an acquired condition in which the length of the small intestine is insufficient to perform its normal absorptive function. Current therapies are limited as the developmental mechanisms that normally regulate elongation of the small intestine are poorly understood. Here, we identify Fgf9 as an important epithelial-to-mesenchymal signal required for proper small intestinal morphogenesis. Mouse embryos that lack either Fgf9 or the mesenchymal receptors for Fgf9 contained a disproportionately shortened small intestine, decreased mesenchymal proliferation, premature differentiation of fibroblasts into myofibroblasts and significantly elevated Tgfbeta signaling. These findings suggest that Fgf9 normally functions to repress Tgfbeta signaling in these cells. In vivo, a small subset of mesenchymal cells expressed phospho-Erk and the secreted Tgfbeta inhibitors Fst and Fstl1 in an Fgf9-dependent fashion. The p-Erk/Fst/Fstl1-expressing cells were most consistent with intestinal mesenchymal stem cells (iMSCs). We found that isolated iMSCs expressed p-Erk, Fst and Fstl1, and could repress the differentiation of intestinal myofibroblasts in co-culture. These data suggest a model in which epithelial-derived Fgf9 stimulates iMSCs that in turn regulate underlying mesenchymal fibroblast proliferation and differentiation at least in part through inhibition of Tgfbeta signaling in the mesenchyme. Taken together, the interaction of FGF and TGFbeta signaling pathways in the intestinal mesenchyme could represent novel targets for future short bowel syndrome therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.