ArticleDevelopment (Cambridge, England)2008
Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- EGR3 regulates opioid-related nociception and motivation in male rats.Psychopharmacology · 2022Article
- A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders.Molecular neurobiology · 2022Review
- The sympathetic nervous system in development and disease.Nature reviews. Neuroscience · 2021Review
- Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia.Brain imaging and behavior · 2021Article
- Loss of EGR3 is an independent risk factor for metastatic progression in prostate cancer.Oncogene · 2020Article
- The many disguises of the signalling endosome.FEBS letters · 2018Review
- Mechanisms of neurotrophin trafficking via Trk receptors.Molecular and cellular neurosciences · 2018Review
- Article
- Intrinsic Axonal Growth and the Drive for Regeneration.Frontiers in neuroscience · 2016Review
- Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation.Development (Cambridge, England) · 2014Article
- Neuron Culture from Mouse Superior Cervical Ganglion.Bio-protocol · 2014Article
- Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses.The American journal of pathology · 2013Article
- Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia.Neural regeneration research · 2013Article
- Fear-enhancing effects of septal oxytocin receptors.Nature neuroscience · 2013Article
- Proliferation and cell cycle dynamics in the developing stellate ganglion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer.PloS one · 2013Article
- Endocytic trafficking of neurotrophins in neural development.Trends in cell biology · 2012Review
- Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.Endocrinology · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Sympathetic nervous system development depends upon many factors that mediate neuron migration, differentiation and survival. Target tissue-derived nerve growth factor (NGF) signaling-induced gene expression is required for survival, differentiation and target tissue innervation of post-migratory sympathetic neurons. However, the transcriptional regulatory mechanisms mediated by NGF signaling are very poorly defined. Here, we identify Egr3, a member of the early growth response (Egr) family of transcriptional regulators, as having an important role in sympathetic nervous system development. Egr3 is regulated by NGF signaling and it is expressed in sympathetic neurons during development when they depend upon NGF for survival and target tissue innervation. Egr3-deficient mice have severe sympathetic target tissue innervation abnormalities and profound physiological dysautonomia. Unlike NGF, which is essential for sympathetic neuron survival and for axon branching within target tissues, Egr3 is required for normal terminal axon extension and branching, but not for neuron survival. The results indicate that Egr3 is a novel NGF signaling effector that regulates sympathetic neuron gene expression required for normal target tissue innervation and function. Egr3-deficient mice have a phenotype that is remarkably similar to humans with sympathetic nervous system disease, raising the possibility that it may have a role in some forms of human dysautonomia, most of which have no known cause.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.