ArticleNucleic acids research2008
Trans-natural antisense transcripts including noncoding RNAs in 10 species: implications for expression regulation.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Identification cloning and functional analysis of novel natural antisense lncRNA CFL1-AS1 in cattle.Epigenetics · 2023Article
- Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation.Scientific reports · 2021Article
- Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark.Journal of experimental & clinical cancer research : CR · 2020Review
- Antisense regulation of atrial natriuretic peptide expression.JCI insight · 2019Article
- Prediction of regulatory long intergenic non-coding RNAs acting in trans through base-pairing interactions.BMC genomics · 2019Article
- Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers.International journal of molecular sciences · 2018Review
- Article
- Functional elucidation of the non-coding RNAs of Kluyveromyces marxianus in the exponential growth phase.BMC genomics · 2016Article
- Long non-coding RNAs as novel expression signatures modulate DNA damage and repair in cadmium toxicology.Scientific reports · 2015Article
- An antisense RNA-mediated mechanism eliminates a meiosis-specific copper-regulated transcript in mitotic cells.The Journal of biological chemistry · 2015Article
- A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression.Scientific reports · 2015Article
- From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease.Endocrine reviews · 2015Review
- A Systematic Analysis on mRNA and MicroRNA Expression in Runting and Stunting Chickens.PloS one · 2015Article
- Development of genodynamic metrics for exploring the biophysics of DNA polymorphisms.Journal of computational biology and bioinformatics research · 2014Article
- Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs.Epigenetics · 2014Review
- A rice cis-natural antisense RNA acts as a translational enhancer for its cognate mRNA and contributes to phosphate homeostasis and plant fitness.The Plant cell · 2013Article
- Comparative transcriptome analysis of small noncoding RNAs in different stages of Trypanosoma brucei.RNA (New York, N.Y.) · 2013Article
- Regulatory mechanisms of long noncoding RNAs in vertebrate central nervous system development and function.Neuroscience · 2013Review
- Zinc-dependent regulation of the Adh1 antisense transcript in fission yeast.The Journal of biological chemistry · 2013Article
- Natural antisense transcripts in plants: a review and identification in soybean infected with Phakopsora pachyrhizi SuperSAGE library.TheScientificWorldJournal · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Natural antisense transcripts are at least partially complementary to their sense transcripts. Cis-Sense/Antisense pairs (cis-SAs) have been extensively characterized and known to play diverse regulatory roles, whereas trans-Sense/Antisense pairs (trans-SAs) in animals are poorly studied. We identified long trans-SAs in human and nine other animals, using ESTs to increase coverage significantly over previous studies. The percentage of transcriptional units (TUs) involved in trans-SAs among all TUs was as high as 4.13%. Particularly 2896 human TUs (or 2.89% of all human TUs) were involved in 3327 trans-SAs. Sequence complementarities over multiple segments with predicted RNA hybridization indicated that some trans-SAs might have sophisticated RNA-RNA pairing patterns. One-fourth of human trans-SAs involved noncoding TUs, suggesting that many noncoding RNAs may function by a trans-acting antisense mechanism. TUs in trans-SAs were statistically significantly enriched in nucleic acid binding, ion/protein binding and transport and signal transduction functions and pathways; a significant number of human trans-SAs showed concordant or reciprocal expression pattern; a significant number of human trans-SAs were conserved in mouse. This evidence suggests important regulatory functions of trans-SAs. In 30 cases, trans-SAs were related to cis-SAs through paralogues, suggesting a possible mechanism for the origin of trans-SAs. All trans-SAs are available at http://trans.cbi.pku.edu.cn/.
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Registered trials
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