ArticleJournal of virology2008
Cytopathogenicity of classical Swine Fever virus correlates with attenuation in the natural host.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Evolution of Porcine Virus Isolation: Guidelines for Practical Laboratory Application.Microorganisms · 2025Review
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- DNAJC14-Independent Replication of the Atypical Porcine Pestivirus.Journal of virology · 2022Article
- A double deletion prevents replication of the pestivirus bovine viral diarrhea virus in the placenta of pregnant heifers.PLoS pathogens · 2021Article
- Characterization of a Cytopathogenic Reporter CSFV.Viruses · 2021Article
- CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses.Journal of virology · 2019Article
- Molecular chaperone Jiv promotes the RNA replication of classical swine fever virus.Virus genes · 2017Article
- A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis.PLoS pathogens · 2017Article
- Article
- Autocatalytic cleavage within classical swine fever virus NS3 leads to a functional separation of protease and helicase.Journal of virology · 2013Article
- Interactive cellular proteins related to classical swine fever virus non-structure protein 2 by yeast two-hybrid analysis.Molecular biology reports · 2012Article
- RNA structural elements determine frequency and sites of nonhomologous recombination in an animal plus-strand RNA virus.Journal of virology · 2012Article
- Classical swine fever virus p7 protein is a viroporin involved in virulence in swine.Journal of virology · 2012Article
- Pestivirus virion morphogenesis in the absence of uncleaved nonstructural protein 2-3.Journal of virology · 2012Article
- The core protein of classical Swine Fever virus is dispensable for virus propagation in vitro.PLoS pathogens · 2012Article
- Identification of host cell binding peptide from an overlapping peptide library for inhibition of classical swine fever virus infection.Virus genes · 2011Article
- Biosynthesis of classical swine fever virus nonstructural proteins.Journal of virology · 2011Article
- Two overlapping domains of a lyssavirus matrix protein that acts on different cell death pathways.Journal of virology · 2010Article
- Cytopathic bovine viral diarrhea viruses (BVDV): emerging pestiviruses doomed to extinction.Veterinary researchReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the important livestock pathogens classical swine fever virus (CSFV) and bovine viral diarrhea virus (BVDV), cytopathogenic (cp) and non-cp viruses are distinguished according to the induction of apoptosis in infected tissue culture cells. However, it is currently unknown whether cp CSFV differs from non-cp CSFV with regard to virulence in the acutely infected host. In this study, we generated helper virus-independent CSFV Alfort-Jiv, which encompasses sequences encoding domain Jiv-90 of cellular J-domain protein interacting with viral protein (Jiv). Expanding the knowledge of BVDV, our results suggest that Jiv acts as a regulating cofactor for the nonstructural (NS) protein NS2 autoprotease of CSFV and initiates NS2-3 cleavage in trans. For Alfort-Jiv, the resulting expression of large amounts of NS3 correlated with increased viral RNA synthesis and viral cytopathogenicity. Moreover, both cp Alfort-Jiv and the parental non-cp CSFV strain Alfort-p447 efficiently replicate in cell culture. Animal experiments demonstrated that in contrast to parental non-cp Alfort-p447, infection with cp Alfort-Jiv did not cause disease in pigs but induced high levels of neutralizing antibodies, thus elucidating that cp CSFV is highly attenuated in its natural host. In contrast to virulent Alfort-p447, the attenuated CSFV strain Alfort-Jiv induces the expression of cellular Mx protein in porcine PK-15 cells. Accordingly, the remarkable difference between cp and non-cp CSFV with regard to the ability to cause classical swine fever in pigs correlates with different effects of cp and non-cp CSFV on cellular antiviral defense mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.