ArticleBrain pathology (Zurich, Switzerland)2009
Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly.
Article in Brain pathology (Zurich, Switzerland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme.The FEBS journal · 2016Article
- Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.Molecular genetics and metabolism · 2015Article
- Partial depletion of striatal dopamine enhances penetrance of cognitive deficits in a transgenic mouse model of Alzheimer's disease.Journal of neuroscience research · 2015Article
- Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease.Journal of neuropathology and experimental neurology · 2015Article
- Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.Journal of neuropathology and experimental neurology · 2015Article
- Animal models of Alzheimer disease.Cold Spring Harbor perspectives in medicine · 2012Review
- Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.Brain pathology (Zurich, Switzerland) · 2012Article
- Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease.Cold Spring Harbor perspectives in medicine · 2012Review
- Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Neuroscience · 2012Article
- Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease.Journal of neuropathology and experimental neurology · 2010Article
- Higher soluble amyloid beta concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2010Article
- Neuropathology in the adult changes in thought study: a review.Journal of Alzheimer's disease : JAD · 2009Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Accumulation of abnormal protein aggregates, detergent-insoluble (DI) proteins and amyloid in the brain are shared features of many neurodegenerative diseases. Previous studies correlating DI proteins and cognitive performance are limited. We addressed these limitations using two sets of autopsy brains, one selected from our Alzheimer's Disease Research Center and the other an unselected series from Adult Changes in Thought (ACT), a population-based study of brain aging. We observed concentrations of 11 proteins and 6 protein variants that can be grouped into three highly correlated clusters: amyloid (A)beta, tau and alpha-synuclein (alpha-syn). While abnormal proteins from each cluster independently correlated with cognitive performance in ACT participants, only increased soluble Abeta oligomers in temporal cortex and increased DI Abeta 42 and DI alpha-syn in prefrontal cortex were negatively correlated with cognitive performance. These data underscore the therapeutic imperative to suppress processes leading to accumulation of soluble Abeta oligomers, DI Abeta 42 and DI alpha-syn, highlight an at least partially independent contribution to cognitive impairment and raise the possibility that the priority for therapeutic targets may vary by brain region in a typical elderly US population.
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Registered trials
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