ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
Isolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemus.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 62 citations in OpenAlex.
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- Taxonomic Sampling and Rare Genomic Changes Overcome Long-Branch Attraction in the Phylogenetic Placement of Pseudoscorpions.Molecular biology and evolution · 2021Article
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- Scallop genome provides insights into evolution of bilaterian karyotype and development.Nature ecology & evolution · 2017Article
- Ancestral and novel roles of Pax family genes in mollusks.BMC evolutionary biology · 2017Article
- The Pax gene family: Highlights from cephalopods.PloS one · 2017Article
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- Molecular regionalization in the compact brain of the meiofaunal annelid Dinophilus gyrociliatus (Dinophilidae).EvoDevo · 2016Article
- A conserved genetic mechanism specifies deutocerebral appendage identity in insects and arachnids.Proceedings. Biological sciences · 2015Article
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- Molecular characterization and embryonic origin of the eyes in the common house spider Parasteatoda tepidariorum.EvoDevo · 2015Article
- The expression pattern of the genes engrailed, pax6, otd and six3 with special respect to head and eye development in Euperipatoides kanangrensis Reid 1996 (Onychophora: Peripatopsidae).Development genes and evolution · 2013Article
- Stable transgenesis in the marine annelid Platynereis dumerilii sheds new light on photoreceptor evolution.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Embryonic development and staging of the cobweb spider Parasteatoda tepidariorum C. L. Koch, 1841 (syn.: Achaearanea tepidariorum; Araneomorphae; Theridiidae).Development genes and evolution · 2012Article
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6 authors at 5 institutions in 1 country.
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Abstract
Pax6 regulates eye development in many animals. In addition, Pax6 activates atonal transcription factors in both invertebrate and vertebrate eyes. Here, we investigate the roles of Pax6 and atonal during embryonic development of Limulus polyphemus rudimentary lateral, medial and ventral eyes, and the initiation of lateral ommatidial eye and medial ocelli formation. Limulus eye development is of particular interest because these animals hold a unique position in arthropod phylogeny and possess multiple eye types. Furthermore, the molecular underpinnings of eye development have yet to be investigated in chelicerates. We characterized a Limulus Pax6 gene, with multiple splice products and predicted protein isoforms, and one atonal homologue. Unexpectedly, neither gene is expressed in the developing eye types examined, although both genes are present in the lateral sense organ, a structure of unknown function.
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